Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones

被引：23
|
作者：
Fan, Meiyan [1 ,3 ]
Yang, Wei [1 ,3 ]
He, Min [1 ,3 ]
Li, Yongjun [4 ]
Peng, Zhiyun [2 ]
Wang, Guangcheng [1 ]
机构：
[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang, Peoples R China
[2] Guizhou Med Univ, Off Drug Clin Trial Inst, Affiliated Hosp, Guiyang, Peoples R China
[3] Guizhou Med Univ, Sch Pharm, Teaching & Res Sect Nat Med Chem, Guiyang, Peoples R China
[4] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM Minist, Guiyang, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 237卷
关键词：
2-(2-Phenylethyl)chromone; Occurrence; Synthesis; Biological activities; AGARWOOD QI-NAN; MS-GUIDED ISOLATION; 2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; AGALWOOD JINKO; DIMERIC 2-(2-PHENYLETHYL)CHROMONES; BI-PHENYLETHYLCHROMONES; AQUILARIA SINENSIS; =2-(2-PHENYLETHYL)-4H-1-BENZOPYRAN-4-ONE DERIVATIVES; ARTIFICIAL AGARWOOD; INHIBITORY-ACTIVITY;
D O I：
10.1016/j.ejmech.2022.114397
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2-(2-Phenylethyl)chromones (PECs) are a group of naturally occurring compounds, which are characterized as phenylethyl substituent at the C2 position of chromone. They have been isolated mainly from Aquilaria sinensis (Lour.) Gilg. This type of natural compound is correlative with anti-diabetes, anticancer, antioxidant, antibacterial, anticancer, and anti-inflammatory activities. Due to the versatile activities of PECs, more and more researchers use different improved methods to synthesize them and their derivatives. This review mainly focuses on the natural occurrence, chemical synthesis, and biological activities of PECs, which were published up until 2020.
引用
收藏
页数：13
相关论文
共 50 条
  • [11] A facile synthesis of 2-(2′-vinylthiophene)chromones by the modified Baker-Venkataraman transformation
    Miya, MB
    Ramadas, S
    Krupadanam, GLD
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1998, 37 (06): : 579 - 582
  • [12] SYNTHESIS OF 2-(2-FURYL) CHROMONES BY SELENIUM DIOXIDE OXIDATION OF FURFURYLIDENE CHALCONES
    KUMARI, SS
    RAO, KSR
    RAO, AVS
    RAO, NVS
    CURRENT SCIENCE, 1967, 36 (16): : 430 - &
  • [13] Synthesis of 2-(trifluoroacetyl)chromones and their reactions with 1,2-diamines
    Irgashev, Roman A.
    Safrygin, Alexander V.
    Ezhikova, Marina A.
    Kodess, Mikhail I.
    Roeschenthaler, Gerd-Volker
    Sosnovskikh, Vyacheslav Y.
    TETRAHEDRON, 2015, 71 (12) : 1822 - 1830
  • [14] SYNTHESIS AND BIOLOGICAL SCREENING OF SOME NOVEL 2-HETERYL CHROMONES
    Karale, B. K.
    Chaudhari, C. S.
    Jadhav, R. K.
    Akolkar, H. N.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2011, 20 (04) : 377 - 380
  • [15] SYNTHESIS AND BIOLOGICAL-ACTIVITY SUBSTITUTED OF 2-(4-IMIDAZOLYLETHYLAMINES)
    PLAZZI, PV
    BORDI, F
    VITTO, M
    IMPICCIATORE, M
    FARMACO-EDIZIONE SCIENTIFICA, 1981, 36 (11): : 921 - 931
  • [16] Microwave Assisted Synthesis and Biological Activity of Novel Bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} Derivatives
    Baba, N. H. Kumar
    Ashok, D.
    Rao, Boddu Ananda
    Sarasija, Madderla
    Murthy, N. Y. S.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (03) : 580 - 586
  • [17] Microwave Assisted Synthesis and Biological Activity of Novel Bis{2-[2-(substituted benzylidene)hydrazinyl]thiazole} Derivatives
    N. H. Kumar Baba
    D. Ashok
    Boddu Ananda Rao
    Madderla Sarasija
    N. Y. S. Murthy
    Russian Journal of General Chemistry, 2018, 88 : 580 - 586
  • [18] Synthesis and Biological Activity of Substituted 2-[2-(Diphenylmethylene)hydrazinyl]-5,5-dimethyl-4-oxohex-2-enoates
    Siutkina, A. I.
    Chashchina, S. V.
    Makhmudov, R. R.
    Kizimova, I. A.
    Shipilovskikh, S. A.
    Igidov, N. M.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 57 (11) : 1874 - 1881
  • [19] Synthesis and Biological Activity of Substituted 2-[2-(Diphenylmethylene)hydrazinyl]-5,5-dimethyl-4-oxohex-2-enoates
    A. I. Siutkina
    S. V. Chashchina
    R. R. Makhmudov
    I. A. Kizimova
    S. A. Shipilovskikh
    N. M. Igidov
    Russian Journal of Organic Chemistry, 2021, 57 : 1874 - 1881
  • [20] Reactions of 2-(trifluoroacetyl)chromones with aromatic amines
    Alexander V. Safrygin
    Darya A. Vetyugova
    Roman A. Irgashev
    Vyacheslav Ya. Sosnovskikh
    Chemistry of Heterocyclic Compounds, 2017, 53 : 1362 - 1364
12345