Occurrence, synthesis and biological activity of 2-(2-phenyethyl)chromones

被引：23

作者：

Fan, Meiyan ^{[1
,3
]}

Yang, Wei ^{[1
,3
]}

He, Min ^{[1
,3
]}

Li, Yongjun ^{[4
]}

Peng, Zhiyun ^{[2
]}

Wang, Guangcheng ^{[1
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang, Peoples R China

[2] Guizhou Med Univ, Off Drug Clin Trial Inst, Affiliated Hosp, Guiyang, Peoples R China

[3] Guizhou Med Univ, Sch Pharm, Teaching & Res Sect Nat Med Chem, Guiyang, Peoples R China

[4] Guizhou Med Univ, Engn Res Ctr Dev & Applicat Ethn Med & TCM Minist, Guiyang, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 237卷

关键词：

2-(2-Phenylethyl)chromone; Occurrence; Synthesis; Biological activities; AGARWOOD QI-NAN; MS-GUIDED ISOLATION; 2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; AGALWOOD JINKO; DIMERIC 2-(2-PHENYLETHYL)CHROMONES; BI-PHENYLETHYLCHROMONES; AQUILARIA SINENSIS; =2-(2-PHENYLETHYL)-4H-1-BENZOPYRAN-4-ONE DERIVATIVES; ARTIFICIAL AGARWOOD; INHIBITORY-ACTIVITY;

D O I：

10.1016/j.ejmech.2022.114397

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-(2-Phenylethyl)chromones (PECs) are a group of naturally occurring compounds, which are characterized as phenylethyl substituent at the C2 position of chromone. They have been isolated mainly from Aquilaria sinensis (Lour.) Gilg. This type of natural compound is correlative with anti-diabetes, anticancer, antioxidant, antibacterial, anticancer, and anti-inflammatory activities. Due to the versatile activities of PECs, more and more researchers use different improved methods to synthesize them and their derivatives. This review mainly focuses on the natural occurrence, chemical synthesis, and biological activities of PECs, which were published up until 2020.

引用

页数：13

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