Fluorescence-guided surgery for high-grade gliomas

被引：59
|
作者：
Lakomkin, Nikita [1 ,2 ]
Hadjipanayis, Constantinos G. [1 ,2 ]
机构：
[1] Mt Sinai Hlth Syst, Icahn Sch Med Mt Sinai, Dept Neurosurg, New York, NY USA
[2] Mt Sinai Hlth Syst, Mt Sinai Beth Israel, Icahn Sch Med, Dept Neurosurg, New York, NY USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2018年 / 118卷 / 02期
关键词：
5-aminolevulinic acid (5-ALA); glioblastoma multiforme (GBM); photodynamic therapy; INDUCED PROTOPORPHYRIN-IX; INTERSTITIAL PHOTODYNAMIC THERAPY; COMBINING 5-AMINOLEVULINIC ACID; MALIGNANT BRAIN-TUMORS; OF-THE-LITERATURE; GLIOBLASTOMA-MULTIFORME; INTRAOPERATIVE FLUORESCENCE; PHASE-II; IN-VITRO; RESECTION;
D O I：
10.1002/jso.25154
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.
引用
收藏
页码：356 / 361
页数：6
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