Synthesis and Evaluation of Substituted Imidazolones for Antiinflammatory and Antioxidant Activities

A series of 4-substituted benzylidene-2-phenyl-1-substituted phenyl-1H-imidazol-5(4H)-one were synthesized by condensation of substituted oxazolones with p-amino benzoic acid and benzocaine. The chemical structures of synthesized compounds were confirmed by IR, H-1 NMR, mass spectral and elemental analysis. The compounds were evaluated for antiinflammatory and antioxidant activities. Out of these series of compounds screened, the compounds 4, 5, 14 and 16 showed equipotent activity to the standard drug phenylbutazone. Compounds 8 and 17 showed good antioxidant activity.