Objectives. To describe an optimized 3D time-resolved contrast-enhanced MR angiography (3D TR-CE-MRA) at 3T in diagnosing head and neck paragangliomas and assessing their morphology and relation to neighboring vessels. Methods. In a prospective study, eight consecutive patients presenting cranial cervical masses suspected to be 10 paragangliomas were examined with 3D TR-CE-MRA at 3T. Two neuroradiologists evaluated the overall image quality, the presence of a paraganglioma, the maximum diameter, as well as the vessel invasion. Results. In all of the cases, the overall image quality was scored as good. The tumors (n = 10) were all visualized and localized. The mean maximum diameter was 32.7 mm [range 7-80]. Vessel invasion was assessed as uncertain in one case and improbable in nine cases. Conclusion. 3D TR-CE-MRA at 3T associated with conventional sequences facilitates a comprehensive investigation of paragangliomas, thus providing the anatomical and functional information. (c) 2009 Elsevier Masson SAS. All rights reserved.