Preclinical discovery research of E7080, an inhibitor of Vascular Endothelial Growth Factor Receptor (VEGFR) family of tyrosine kinases

被引：0
|
作者：
Funahashi, Yasuhiro [1 ]
机构：
[1] Eisai & Co Ltd, Oncol PCU, Discovery, Tsukuba, Ibaraki 3002635, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2010年 / 112卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：33P / 33P
页数：1
相关论文
共 50 条
  • [21] A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
    Joukov, V
    Pajusola, K
    Kaipainen, A
    Chilov, D
    Lahtinen, I
    Kukk, E
    Saksela, O
    Kalkkinen, N
    Alitalo, K
    EMBO JOURNAL, 1996, 15 (02): : 290 - 298
  • [22] CEP-7055: A novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models
    Ruggeri, B
    Singh, J
    Gingrich, D
    Angeles, T
    Albom, M
    Chang, H
    Robinson, C
    Hunter, K
    Dobrzanski, P
    Jones-Bolin, S
    Aimone, L
    Klein-Szanto, A
    Herbert, JM
    Bono, F
    Schaeffer, P
    Casellas, P
    Bourie, B
    Pili, R
    Isaacs, J
    Ator, M
    Hudkins, R
    Vaught, J
    Mallamo, J
    Dionne, C
    CANCER RESEARCH, 2003, 63 (18) : 5978 - 5991
  • [23] Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma
    Huynh, Hung
    Ngo, Van Chanh
    Fargnoli, Joseph
    Ayers, Mark
    Soo, Khee Chee
    Koong, Heng Nung
    Thng, Choon Hua
    Ong, Hock Soo
    Chung, Alexander
    Chow, Pierce
    Pollock, Pamela
    Byron, Sara
    Tran, Evelyn
    CLINICAL CANCER RESEARCH, 2008, 14 (19) : 6146 - 6153
  • [24] Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)
    Kaufman, Nichole E. M.
    Dhingra, Simran
    Jois, Seetharama D.
    Vicente, Maria da Graca H.
    MOLECULES, 2021, 26 (04):
  • [25] PTK787/ZK222584, an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, decreases glioma growth and vascularization - Comments
    Piepmeier, JM
    Westphal, M
    NEUROSURGERY, 2004, 55 (02) : 432 - 432
  • [26] Effect of Ketoconazole On Pharmacokinetics of Tivozanib, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor
    Cotreau, M.
    Siebers, N.
    Massmanian, L.
    Strahs, A.
    Vargo, D.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : 182 - 183
  • [27] Acquired Drug Resistance to Vascular Endothelial Growth Factor Receptor 2 Tyrosine Kinase Inhibitor in Human Vascular Endothelial Cells
    Arao, Tokuzo
    Matsumoto, Kazuko
    Furuta, Kazuyuki
    Kudo, Kanae
    Kaneda, Hiroyasu
    Nagai, Tomoyuki
    Sakai, Kazuko
    Fujita, Yoshihiko
    Tamura, Daisuke
    Aomatsu, Keiichi
    Koizumi, Fumiaki
    Nishio, Kazuto
    ANTICANCER RESEARCH, 2011, 31 (09) : 2787 - 2796
  • [28] KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties
    Nakamura, Kazuhide
    Taguchi, Eri
    Miura, Toru
    Yamamoto, Atsushi
    Takahashi, Kazumi
    Bichat, Francis
    Guilbaud, Nicolas
    Hasegawa, Kazumasa
    Kubo, Kazuo
    Fujiwara, Yasunari
    Suzuki, Rika
    Kubo, Kinya
    Shibuya, Masabumi
    Isoe, Toshiyuki
    CANCER RESEARCH, 2006, 66 (18) : 9134 - 9142
  • [29] PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
    Wood, JM
    Bold, G
    Buchdunger, E
    Cozens, R
    Ferrari, S
    Frei, J
    Hofmann, F
    Mestan, J
    Mett, H
    O'Reilly, T
    Persohn, E
    Rösel, J
    Schnell, C
    Stover, D
    Theuer, A
    Towbin, H
    Wenger, F
    Woods-Cook, K
    Menrad, A
    Siemeister, G
    Schirner, M
    Thierauch, KH
    Schneider, MR
    Drevs, J
    Martiny-Baron, G
    Totzke, F
    Marmé, D
    CANCER RESEARCH, 2000, 60 (08) : 2178 - 2189
  • [30] E7080 Suppresses Hematogenous Multiple Organ Metastases of Lung Cancer Cells with Nonmutated Epidermal Growth Factor Receptor
    Ogino, Hirokazu
    Hanibuchi, Masaki
    Kakiuchi, Soji
    Van The Trung
    Goto, Hisatsugu
    Ikuta, Kenji
    Yamada, Tadaaki
    Uehara, Hisanori
    Tsuruoka, Akihiko
    Uenaka, Toshimitsu
    Wang, Wei
    Li, Qi
    Takeuchi, Shinji
    Yano, Seiji
    Nishioka, Yasuhiko
    Sone, Saburo
    MOLECULAR CANCER THERAPEUTICS, 2011, 10 (07) : 1218 - 1228
12345