Influence of Lychnis chalcedonica L. Flavonoids on Transplanted Tumor Development and Cytostatic Therapy Effectiveness in Mice

被引：1

作者：

Amosova, E. N. ^{[1
]}

Zueva, E. P. ^{[1
]}

Lopatina, K. A. ^{[1
,2
]}

Safonova, E. A. ^{[1
,2
]}

Razina, T. G. ^{[1
]}

Rybalkina, O. Yu. ^{[1
,2
]}

Zibareva, L. N. ^{[2
]}

机构：

[1] Russian Acad Sci, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk Natl Res Med Ctr, 3 Prosp Lenina, Tomsk 634028, Russia

[2] Tomsk State Univ, 36 Prosp Lenina, Tomsk 634050, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 05期

关键词：

Lychnis chalcedonica flavonoids; transplanted tumors; cytostatic therapy;

D O I：

10.1007/s11094-019-02018-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A complex of biologically active compounds was isolated from Lychnis chalcedonica L. cultivated at the Siberian Botanical Garden at Tomsk State University. HPLC analysis found that the isolated compounds were flavonoids with retention times 10.40, 12.45, 13.29, and 15.47 min. The major flavonoid constituent was vicenin with t(r) = 13.29 min and a peak area of 87.4%. The flavonoid complex of L. chalcedonica was studied using three transplanted tumor models, i.e., Lewis lung carcinoma (LLC), melanoma B-16 (B-16), and lung cancer RL-67 (RL-67). Tests on C57BL/6 mice showed that the L. chalcedonica flavonoid complex inhibited development of melanoma B-16. Co-administration of L. chalcedonica flavonoids and cyclophosphamide enhanced the antitumor effect of the cytostatic in animals with B-16, RL-67, and LLC.

引用

页码：454 / 457

页数：4

共 8 条

[1] Influence of Lychnis chalcedonica L. Flavonoids on Transplanted Tumor Development and Cytostatic Therapy Effectiveness in Mice
E. N. Amosova
E. P. Zueva
K. A. Lopatina
E. A. Safonova
T. G. Razina
O. Yu. Rybalkina
L. N. Zibareva
Pharmaceutical Chemistry Journal, 2019, 53 : 454 - 457
[2] The Effect of Lychnis Chalcedonica L. Flavonoids on the Development of Tumors in Mice and the Effectiveness of Treatment with Cyclophosphamide
Zibareva, L. N.
Zueva, E. P.
Razina, T. G.
Amosova, E. N.
Krylova, S. G.
Lopatina, K. A.
Rybalkina, O. Y.
Badulina, A. A.
Safonova, E. A.
Babushkina, M. S.
Filonenko, E. S.
Galiulina, A. V.
NEW OPERATIONAL TECHNOLOGIES (NEWOT'2015), 2015, 1688
[3] Anti-Inflammatory and Analgesic Activities of the Complex of Flavonoids from Lychnis chalcedonica L.
Yu. V. Nesterova
T. N. Povet’eva
L. N. Zibareva
N. I. Suslov
E. P. Zueva
S. G. Aksinenko
O. G. Afanas’eva
S. G. Krylova
E. N. Amosova
O. Yu. Rybalkina
K. A. Lopatina
Bulletin of Experimental Biology and Medicine, 2017, 163 : 222 - 225
[4] Anti-Inflammatory and Analgesic Activities of the Complex of Flavonoids from Lychnis chalcedonica L.
Nesterova, Yu. V.
Povet'eva, T. N.
Zibareva, L. N.
Suslov, N. I.
Zueva, E. P.
Aksinenko, S. G.
Afanas'eva, O. G.
Krylova, S. G.
Amosova, E. N.
Rybalkina, O. Yu.
Lopatina, K. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2017, 163 (02) : 222 - 225
[5] Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice
E. N. Amosova
I. V. Shilova
E. P. Zueva
O. Yu. Rybalkina
Pharmaceutical Chemistry Journal, 2019, 53 : 458 - 461
[6] Influence of Filipendula ulmaria (L.) Maxim. Extract on Lewis Lung Carcinoma Development and Cytostatic Therapy Effectiveness in Mice
Amosova, E. N.
Shilova, I., V
Zueva, E. P.
Rybalkina, O. Yu
PHARMACEUTICAL CHEMISTRY JOURNAL, 2019, 53 (05) : 458 - 461
[7] INFLUENCE OF THYMUS ON DEVELOPMENT OF TRANSPLANTED MAMMARY TUMOR IN MICE
BELYAEV, DK
GRUNTENKO, EV
INTERNATIONAL JOURNAL OF CANCER, 1972, 9 (01) : 1 - +
[8] INFLUENCE OF L-DOPA ON SPONTANEOUS TUMOR DEVELOPMENT IN MALE MARSH MICE
BRYSON, G
BISCHOFF, F
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1975, 16 (MAR): : 2 - 2

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