Molecular basis of HIV-1 latency Part I: physiology of HIV-1 latency

被引：8

作者：

Schwartz, Christian ^{[1
,2
]}

Le Douce, Valentin ^{[1
]}

Cherrier, Thomas ^{[1
]}

Redel, Laetitia ^{[1
]}

Marban, Wine ^{[1
]}

Aunis, Dominique ^{[1
]}

Rohr, Olivier ^{[1
,2
]}

机构：

[1] INSERM, Unite Physiopathol Syst Nerveux Cent 575, Inst Virol, F-67000 Strasbourg, France

[2] IUT Schiltigheim, F-67300 Schiltigheim, France

来源：

M S-MEDECINE SCIENCES | 2010年 / 26卷 / 02期

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL-ACTIVATION; GENE-EXPRESSION; ANTIRETROVIRAL THERAPY; CHROMATIN; REPLICATION; INFECTION; TRANSCRIPTION; RECRUITMENT; INTEGRATION;

D O I：

10.1051/medsci/2010262159

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Molecular basis of HIV-1 latency Part I: physiology of HIV-1 latency The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1 Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1 Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus

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页码：159 / 163

页数：5

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