Emergence of Indian lineage of ECSA chikungunya virus in Djibouti, 2019

被引:4
|
作者
Fourie, Toscane [1 ,2 ]
Dia, Aissata [3 ]
Savreux, Quentin [4 ]
de Santi, Vincent Pommier [3 ]
de Lamballerie, Xavier [2 ]
Leparc-Goffart, Isabelle [1 ,2 ]
Simon, Fabrice [2 ,5 ]
机构
[1] Ctr Natl Reference Arbovirus, Inst Rech Biomed Armees, Unite Virol, Marseille, France
[2] Aix Marseille Univ, Unite Virus Emergents UVE, IRD 190, INSERM 1207, Marseille, France
[3] Ctr Epidemiol & Sante Publ Armees, Marseille, France
[4] French Mil Med Surg Ctr, Djibouti City, Djibouti
[5] Hop Instruct Armees Laveran, Marseille, France
基金
欧盟地平线“2020”;
关键词
Chikungunya virus; Djibouti; Horn of Africa; Traveler; Sequencing; DENGUE;
D O I
10.1016/j.ijid.2021.03.090
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The chikungunya virus (CHIKV) originated from Africa and has spread worldwide. Since 2017, multiple chikungunya outbreaks have been reported in the Horn of Africa, without molecular characterization. In November 2019, an autochthonous acute chikungunya infection was diagnosed in a French patient living in Djibouti, marking the re-emergence of the virus in the country. The strain was isolated and fully sequenced. Phylogenetic analysis revealed that the Djiboutian strain belongs to the Indian lineage of the Eastern/Central/South African (ECSA) genotype. Two mutations highly increasing the virus's fitness in Aedes aegypti, the sole vector present in Djibouti city, were identified. (c) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/).
引用
收藏
页码:198 / 201
页数:4
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