Incomplete and noisy network data as a percolation process

被引:11
|
作者
Stumpf, Michael P. H. [1 ,2 ]
Wiuf, Carsten [1 ,3 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, Ctr Bioinformat, London SW7 2AZ, England
[2] Univ London Imperial Coll Sci Technol & Med, Inst Math Sci, London SW7 2AZ, England
[3] Univ Aarhus, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
基金
英国生物技术与生命科学研究理事会;
关键词
complex networks; random graphs; protein interaction networks; sampling problems; PROTEIN-INTERACTION DATA; SCALE-FREE; YEAST; COMPLEXES; GRAPHS; SIZE;
D O I
10.1098/rsif.2010.0044
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We discuss the ramifications of noisy and incomplete observations of network data on the existence of a giant connected component (GCC). The existence of a GCC in a random graph can be described in terms of a percolation process, and building on general results for classes of random graphs with specified degree distributions we derive percolation thresholds above which GCCs exist. We show that sampling and noise can have a profound effect on the perceived existence of a GCC and find that both processes can destroy it. We also show that the absence of a GCC puts a theoretical upper bound on the false-positive rate and relate our percolation analysis to experimental protein-protein interaction data.
引用
收藏
页码:1411 / 1419
页数:9
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