Similarities and differences in working memory and neurometabolism of obsessive-compulsive disorder and major depressive disorder

被引:6
|
作者
He, Jiali [1 ]
Yan, Shuya [1 ]
Song, Zijin [2 ]
Lu, Qianyi [2 ]
Zhong, Shuming [1 ]
Lai, Shunkai [1 ]
Wang, Ying [3 ]
Chen, Guanmao [3 ]
Zhao, Hui [1 ]
Chen, Pan [3 ]
Zhang, Yiliang [1 ]
Jia, Yanbin [1 ]
机构
[1] Jinan Univ, Dept Psychiat, Affiliated Hosp 1, Guangzhou 510630, Peoples R China
[2] Jinan Univ, Sch Management, Guangzhou 510316, Peoples R China
[3] Jinan Univ, Med Imaging Ctr, Affiliated Hosp 1, Guangzhou 510630, Peoples R China
基金
中国国家自然科学基金;
关键词
Obsessive-compulsive disorder; Major depressive disorder; Working memory; Neurometabolic mechanism; Prefrontal cortex; DRUG-NAIVE PATIENTS; N-ACETYL-ASPARTATE; PREFRONTAL CORTEX; UNIPOLAR DEPRESSION; NEUROPSYCHOLOGICAL DEFICITS; EXECUTIVE FUNCTIONS; COGNITIVE FUNCTION; ABNORMALITIES; IMPAIRMENT; MARKERS;
D O I
10.1016/j.jad.2022.05.069
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment. However, there are limited comparative working memory (WM) and neuroimaging studies on these two disorders. Therefore, we investigated the characteristics of WM and neurometabolic changes in patients with OCD and MDD. Methods: A total of 64 unmedicated patients (32 OCD and 32 MDD), and 33 healthy controls (HC) were included to conduct WM assessment comprising Digit Span Test (DST), 2-back task and Stroop Color and Word Test (SCWT). Additionally, all subjects underwent protons magnetic resonance spectroscopy (1H-MRS) to collect neurometabolic ratios of N-acetyl aspartate (NAA) and choline-containing compounds (Cho) to creatine (Cr) in the prefrontal cortex (PFC) and lentiform nucleus (LN). Finally, differential and correlation analysis were conducted to investigate their characteristics and relationships. Results: Compared with HC, both OCD and MDD patients exhibited a lower accuracy rate in the 2-back task, and only MDD patients performed worse in DST scores and longer reaction times in SCWT (all p < 0.05). Both OCD and MDD patients had lower NAA/Cr ratios in bilateral PFC (all p < 0.05). And the decreased NAA/Cr ratios in right PFC were positively correlated to DST scores in MDD group (r = 0.518, p = 0.003). Conclusions: Both OCD and MDD showed WM impairment and neurometabolic alterations in PFC. Besides, MDD performed more severe and broader WM impairment compared to OCD. Moreover, the dysfunction of PFC may underlie the neural basis of WM impairment in MDD.
引用
收藏
页码:556 / 564
页数:9
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