ULIPRISTAL ACETATE FOR UTERINE FIBROID-RELATED SYMPTOMS

被引：4

作者：

Puchar, A. ^{[1
]}

Luton, D. ^{[1
]}

Koskas, M. ^{[1
]}

机构：

[1] Paris Diderot Univ, Obstet & Gynecol, Bichat Univ Hosp, Paris, France

来源：

DRUGS OF TODAY | 2015年 / 51卷 / 11期

关键词：

Ulipristal acetate; Uterine fibroids; Uterine tumors; progesterone receptor modulators; PROGESTERONE-RECEPTOR MODULATOR; WOMEN; PLACEBO; PHARMACOKINETICS; LEIOMYOMATA; ASOPRISNIL; MANAGEMENT; EFFICACY; MYOMAS; IMPACT;

D O I：

10.1358/dot.2015.51.11.2413469

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Uterine fibroids are the most common benign uterine tumors in women of reproductive age. Although most women are asymptomatic (80%), fibroids, according to their type and location, can cause several symptoms and impact quality of life. To date, no medical treatment is able to eliminate fibroids. Ulipristal acetate (UPA) is an orally active synthetic selective progesterone receptor modulator (SPRM) characterized by a tissue-specific progesterone antagonist effect that reduces the proliferation of leiomyoma cells and induces apoptosis. It was licensed in Europe for preoperative fibroid treatment in 2012. Its pharmacological and pharmacodynamic characteristics, its efficacy and good tolerance make UPA a new important tool in the management of uterine fibroids.

引用

页码：661 / 667

页数：7

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