ADX10059 a Negative Allosteric Modulator of the Metabotropic Glutamate 5 Receptor (mGlur5) Effectively Controls Chorea and Dystonia in a Primate Model of Levodopa Induced Dyskinesia

被引:0
|
作者
Keywood, Charlotte G.
Bezard, Erwan
Girard, Francoise
Mutel, Vincent
机构
关键词
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:A393 / A393
页数:1
相关论文
共 50 条
  • [31] Targeting the type 5 metabotropic glutamate receptor (mGluR5) in a mouse model of terminal neurodegenerative disease
    Budgett, Rebecca
    Bradley, Sophie
    Molloy, Colin
    BRITISH JOURNAL OF PHARMACOLOGY, 2021, 178 (02) : 466 - 467
  • [32] Preclinical Andclinical Evaluation of Dipraglurant: a Novel Negative Allosteric Modulator (NAM) of the mGlu5 Receptor for the Treatment of Dystonia and Levodopa Induced Dyskinesia
    Poli, Sonia
    CURRENT NEUROPHARMACOLOGY, 2014, 12 : 52 - 53
  • [33] Centrally active positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGluR5) for traumatic brain injury (TBI)
    He, Xinhua
    Hanscom, Marie
    Stoica, Bogdan
    MacKerell, Alexander D., Jr.
    Fedan, Alan I.
    Xue, Fengtian
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [34] A novel antagonist of metabotropic 5 glutamate receptors (mGluR5) abolishes L-DOPA-induced dyskinesia in hemiparkinsonian rats
    Dekundy, A.
    Hechenberger, M.
    van der Elst, M.
    Nagel, J.
    Mela, F.
    Tober, C.
    Parsons, C. G.
    Danysz, W.
    MOVEMENT DISORDERS, 2011, 26 : S279 - S279
  • [35] Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in a ketamine-based animal model of schizophrenia
    Zurawek, Dariusz
    Salerno-Kochan, Anna
    Dziedzicka-Wasylewska, Marta
    Nikiforuk, Agnieszka
    Kos, Tomasz
    Popik, Piotr
    SCHIZOPHRENIA RESEARCH, 2018, 192 : 423 - 430
  • [36] Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy - Comparison to MPEP
    Nagel, Jens
    Greco, Sergio
    Parsons, Chris G.
    Flik, Gunnar
    Tober, Carsten
    Klein, Kai-Uwe
    Danysz, Wojciech
    PHARMACOLOGICAL REPORTS, 2015, 67 (03) : 624 - 630
  • [37] Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy — Comparison to MPEP
    Jens Nagel
    Sergio Greco
    Chris G. Parsons
    Gunnar Flik
    Carsten Tober
    Kai-Uwe Klein
    Wojciech Danysz
    Pharmacological Reports, 2015, 67 : 624 - 630
  • [38] Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives
    Selvam, Chelliah
    Thilagavathi, Ramasamy
    Narasimhan, Balasubramanian
    Kumar, Pradeep
    Jordan, Brian C.
    Ranganna, Kasturi
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (04) : 1140 - 1144
  • [39] Expression of metabotropic glutamate receptor 5 (mGluR5) is increased in astrocytes after kainate (KA)-induced epileptic seizures
    Ulas, J
    Satou, T
    Ivins, K
    Kesslak, JP
    Cotman, CW
    Balazs, R
    JOURNAL OF NEUROCHEMISTRY, 1999, 73 : S147 - S147
  • [40] Computational Analysis of Negative and Positive Allosteric Modulator Binding and Function in Metabotropic Glutamate Receptor 5 (In)Activation
    Dalton, James A. R.
    Gomez-Santacana, Xavier
    Llebaria, Amadeu
    Giraldo, Jesus
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2014, 54 (05) : 1476 - 1487