Titanium-mediated synthesis of bicyclic cyclopropylamines from unsaturated nitriles

被引：37

作者：

Laroche, C ^{[1
]}

Bertus, P ^{[1
]}

Szymoniak, J ^{[1
]}

机构：

[1] Univ Reims, CNRS, UMR 6519 React Select & Applicat, UFR Sci, F-51687 Reims 2, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 12期

关键词：

bicyclic compounds; cyclizations; cyclopropanes; nitriles; titanium;

D O I：

10.1016/S0040-4039(03)00325-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we report an easy synthesis of bicyclic primary cyclopropylamines directly from unsaturated nitriles. The described reaction involves Ti(II)-mediated intramolecular coupling of alkene and nitrile moieties. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：2485 / 2487

页数：3

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