Objectives: To provide an overview of transfusion reactions, their underlying pathophysiology, clinical presentation, and recommendations for nursing management. Data Sources: We researched peer-reviewed journal articles, book chapters, Internet, and lecture proceedings. Conclusion: Transfusion reactions are adverse reactions to blood products frequently seen in the oncology population and can significantly vary in severity and etiology. Oncology nurses are in a critical position to assist with prevention, early detection, and time-sensitive treatment of transfusion reactions. Implications for Nursing Practice: : The oncology nurse's comprehensive understanding of possible transfusion reactions and management recommendations is key for optimal care of the oncology patient. (c) 2021 Published by Elsevier Inc.