SURVEILLANCE OF TRANSMITTED RESISTANCE TO ANTIRETROVIRAL DRUG CLASSES AMONG YOUNG CHILDREN IN THE WESTERN CAPE PROVINCE OF SOUTH AFRICA

被引：10

作者：

van Zyl, Gert U. ^{[1
]}

Cotton, Mark F. ^{[2
]}

Claassen, Mathilda ^{[1
]}

Abrahams, Charmaine ^{[1
]}

Preiser, Wolfgang ^{[1
]}

机构：

[1] Univ Stellenbosch, Div Med Virol, ZA-7505 Tygerberg, South Africa

[2] Univ Stellenbosch, Tygerberg Childrens Hosp, Childrens Infect Dis Clin Res Unit, Dept Paediat & Child Hlth, ZA-7505 Tygerberg, South Africa

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2010年 / 29卷 / 04期

关键词：

transmitted antiretroviral drug resistance; surveillance; children; South Africa; INFECTED INFANTS; UGANDAN INFANTS; HIV-INFECTION; MUTATIONS; PREDOMINANCE; PREVALENCE; NEVIRAPINE; VARIANTS; THERAPY; UPDATE;

D O I：

10.1097/INF.0b013e3181c4dada

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants.

引用

页码：370 / 371

页数：2

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