Bright red-emitting pyrene derivatives with a large Stokes shift for nucleus staining

被引：82
|
作者：
Abeywickrama, Chathura S. [1 ]
Wijesinghe, Kaveesha J. [2 ]
Stahelin, Robert V. [2 ,3 ]
Pang, Yi [1 ,4 ]
机构：
[1] Univ Akron, Dept Chem, Akron, OH 44325 USA
[2] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
[3] Indiana Univ Sch Med, Dept Biochem & Mol Biol, South Bend, IN 46617 USA
[4] Univ Akron, Maurice Morton Inst Polymer Sci, Akron, OH 44325 USA
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 43期
关键词：
DNA; FLUORESCENT; CELL; DRAQ5;
D O I：
10.1039/c7cc03417b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly fluorescent red-emitting pyrene derivative was synthesized and found to exhibit a large Stokes shift (lambda(em) approximate to 610 nm, Delta lambda similar to 130 nm, Delta upsilon similar to 4597 cm(-1)). The probe molecule showed remarkable selectivity to stain the nucleus in both live and fixed cells, with higher sensitivity than commercial dye DRAQ5.
引用
收藏
页码：5886 / 5889
页数：4
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