Immunomodulating Properties of Humic Acids Extracted from Oligotrophic Sphagnum magellanicum Peat

被引：7
|
作者：
Trofimova, E. S. [1 ]
Zykova, M., V [2 ]
Danilets, M. G. [1 ]
Ligacheva, A. A. [1 ]
Sherstoboev, E. Yu [1 ]
Tsupko, A., V [2 ]
Mikhalyov, D. A. [2 ]
Belousov, M., V [2 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 170卷 / 04期
基金：
俄罗斯科学基金会;
关键词：
humic acids; cytokines; humoral immune response; peritoneal macrophages; mononuclear cells; TNF-ALPHA; ACTIVATION;
D O I：
10.1007/s10517-021-05088-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Humic acids extracted with sodium pyrophosphate from Oligotrophic Sphagnum magellanicum peat reduce mitogen-stimulated production of anti-inflammatory cytokine IL-10 by mouse peritoneal macrophages and do not affect the secretion of IL-4 by lymphocytes. The studied humic acid sample stimulates the production of proinflammatory cytokines IL-12, TNF alpha, IL-1 beta, and IFN gamma by immunocompetent mouse cells and human mononuclear cells. Course administration of humic acids to mice enhances the humoral immunity, increasing the number of antibody-forming cells in the spleen and the titer of antibodies in the blood serum after immunization with sheep red blood cells.
引用
收藏
页码：461 / 465
页数：5
相关论文
共 50 条
  • [31] Comparison of the Properties of Humic Acids Extracted from Soils by Alkali in the Presence and Absence of Oxygen
    A. G. Zavarzina
    E. G. Kravchenko
    A. I. Konstantinov
    I. V. Perminova
    S. N. Chukov
    V. V. Demin
    Eurasian Soil Science, 2019, 52 : 880 - 891
  • [32] Comparison of the Properties of Humic Acids Extracted from Soils by Alkali in the Presence and Absence of Oxygen
    Zavarzina, A. G.
    Kravchenko, E. G.
    Konstantinov, A. I.
    Perminova, I. V.
    Chukov, S. N.
    Demin, V. V.
    EURASIAN SOIL SCIENCE, 2019, 52 (08) : 880 - 891
  • [33] Role of modified humic acids from peat in the detoxification of tebuconazole
    E. V. Mal’tseva
    D. A. Filatov
    N. V. Yudina
    O. N. Chaikovskaya
    Solid Fuel Chemistry, 2011, 45 : 62 - 67
  • [34] Role of modified humic acids from peat in the detoxification of tebuconazole
    Mal'tseva, E. V.
    Filatov, D. A.
    Yudina, N. V.
    Chaikovskaya, O. N.
    SOLID FUEL CHEMISTRY, 2011, 45 (01) : 62 - 67
  • [35] Effect of soil depth on acid properties of humic substances extracted from an ombrotrophic peat bog in northwest Spain
    Gondar, D
    López, R
    Fiol, S
    Antelo, JM
    Arce, F
    EUROPEAN JOURNAL OF SOIL SCIENCE, 2005, 56 (06) : 793 - 801
  • [36] Effect of the alkylation of brown coal and peat on the composition and properties of humic acids isolated from them
    S. I. Zherebtsov
    Z. R. Ismagilov
    Solid Fuel Chemistry, 2012, 46 : 339 - 351
  • [37] Effect of the alkylation of brown coal and peat on the composition and properties of humic acids isolated from them
    Zherebtsov, S. I.
    Ismagilov, Z. R.
    SOLID FUEL CHEMISTRY, 2012, 46 (06) : 339 - 351
  • [38] Degradation capacity of humic acids-degrading bacteria on humic acids extracted from arable soil
    Fu, Donglei
    Liu, Mengyun
    Chang, Qingrui
    Liu, Liwen
    Lv, Aihua
    ZEMDIRBYSTE-AGRICULTURE, 2017, 104 (01) : 9 - 14
  • [39] Influence of Humic Acids Isolated from Raised Bog Sphagnum Peat on Development of Th1/Th2 Immune Response
    Trofimova, E. S.
    Zykova, M. V.
    Sherstoboev, E. Yu.
    Danilets, M. G.
    Ligacheva, A. A.
    Belousov, M. V.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2022, 174 (02) : 236 - 240
  • [40] Influence of Humic Acids Isolated from Raised Bog Sphagnum Peat on Development of Th1/Th2 Immune Response
    E. S. Trofimova
    M. V. Zykova
    E. Yu. Sherstoboev
    M. G. Danilets
    A. A. Ligacheva
    M. V. Belousov
    Bulletin of Experimental Biology and Medicine, 2022, 174 : 236 - 240
12345