Expression patterns of WNT/β-CATENIN signaling molecules during human tooth development

被引：52
|
作者：
Wang, Bingmei [1 ]
Li, Hanliang [1 ]
Liu, Ying [1 ]
Lin, Xin [1 ]
Lin, Yao [1 ]
Wang, Ye [1 ]
Hu, Xuefeng [1 ]
Zhang, Yanding [1 ]
机构：
[1] Fujian Normal Univ, Coll Life Sci, Fujian Key Lab Dev & Neuro Biol, Fuzhou 350108, Fujian, Peoples R China
来源：
JOURNAL OF MOLECULAR HISTOLOGY | 2014年 / 45卷 / 05期
关键词：
WNT/beta-CATENIN signaling; Human tooth germ; Gene expression; Transcriptional factors; Growth factors; ADENOID CYSTIC CARCINOMA; EPITHELIAL-MESENCHYMAL INTERACTIONS; DEVELOPING MOUSE TOOTH; BETA-CATENIN; ADENOMATOUS POLYPOSIS; MUTATION; WNT5A; PATHWAY; GENES; DIFFERENTIATION;
D O I：
10.1007/s10735-014-9572-5
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The WNT/beta-CATENIN signaling has been demonstrated to play critical roles in mouse tooth development, but little is known about the status of these molecules in human embryonic tooth. In this study, expression patterns of WNT/beta-CATENIN signaling components, including WNT ligands (WNT3, WNT5A), receptors (FZD4, FZD6, LRP5), transducers (beta-CATENIN), transcription factors (TCF4, LEF1) and antagonists (DKK1, SOSTDC1) were investigated in human tooth germ at the bud, cap and bell stages by in situ hybridization. All these genes exhibited similar but slightly distinct expression patterns in human tooth germ in comparison with mouse. Furthermore the mRNA expression of these genes in incisors and molars at the bell stage was also examined by real-time PCR. Our results reveal the status of active WNT/beta-CATENIN signaling in the human tooth germ and suggest these components may also play an essential role in the regulation of human tooth development.
引用
收藏
页码：487 / 496
页数：10
相关论文
共 50 条
  • [41] Development of anticancer agents targeting the Wnt/β-catenin signaling
    Zhang, Xiangqian
    Hao, Jijun
    AMERICAN JOURNAL OF CANCER RESEARCH, 2015, 5 (08): : 2344 - 2360
  • [42] AN ECTOPIC EXPRESSION OF CFTR IN HUMAN BASAL CELLS INHIBITS WNT/β-CATENIN SIGNALING AND PROLIFERATION
    Yang, J.
    Yu, M.
    Cai, Q.
    Liu, X.
    Engelhardt, J.
    PEDIATRIC PULMONOLOGY, 2019, 54 : S192 - S193
  • [43] Wnt/β-catenin signaling in xenopus retinal development.
    Van Raay, TJ
    Jamrich, M
    Vetter, ML
    DEVELOPMENTAL BIOLOGY, 2003, 259 (02) : 564 - 564
  • [44] Wnt/β-catenin signaling is required for development of the exocrine pancreas
    Wells, James M.
    Esni, Farzad
    Boivin, Gregory P.
    Aronow, Bruce J.
    Stuart, William
    Combs, Chelsea
    Sklenka, Angela
    Leach, Steven D.
    Lowy, Andrew M.
    BMC DEVELOPMENTAL BIOLOGY, 2007, 7
  • [45] Requirement of Wnt/β-catenin signaling in pronephric kidney development
    Lyons, Jon P.
    Miller, Rachel K.
    Zhou, Xiaolan
    Weidinger, Gilbert
    Deroo, Tom
    Denayer, Tinneke
    Park, Jae-Il
    Ji, Hong
    Hong, Ji Yeon
    Li, Annette
    Moon, Randall T.
    Jones, Elizabeth A.
    Vleminckx, Kris
    Vize, Peter D.
    McCrea, Pierre D.
    MECHANISMS OF DEVELOPMENT, 2009, 126 (3-4) : 142 - 159
  • [46] Involvement of Wnt/β-catenin signaling in the development of neuropathic pain
    Itokazu, Takahide
    Hayano, Yasufumi
    Takahashi, Ryosuke
    Yamashita, Toshihide
    NEUROSCIENCE RESEARCH, 2014, 79 : 34 - 40
  • [47] Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
    Russell, Jacquelyn O.
    Monga, Satdarshan P.
    ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13, 2018, 13 : 351 - 378
  • [48] Intervertebral Disc Development Is Regulated by Wnt/β-catenin Signaling
    Kondo, Naoki
    Yuasa, Takahito
    Shimono, Kengo
    Tung, Weien
    Okabe, Takahiro
    Yasuhara, Rika
    Pacifici, Maurizio
    Zhang, Yejia
    Iwamoto, Masahiro
    Enomoto-Iwamoto, Motomi
    SPINE, 2011, 36 (08) : E513 - E518
  • [49] The Wnt/β-catenin Signaling Pathway in Melanocyte and Melanoma Development
    Delmas, V.
    Champeval, D.
    Fuciani, F.
    Herbette, A.
    Kumasaka, M.
    Alberti, C.
    Demirkan, N.
    Larue, L.
    PROCEEDINGS OF THE XXTH INTERNATIONAL PIGMENT CELL CONFERENCE - IPCC AND VTH INTERNATIONAL MELANOMA RESEARCH CONGRESS - IMRC, 2008, : 63 - 68
  • [50] Expression of Wnt Signaling Components during Xenopus Pronephros Development
    Zhang, Bo
    Tran, Uyen
    Wessely, Oliver
    PLOS ONE, 2011, 6 (10):
12345