Ligand free copper-catalyzed N-arylation of heteroarylamines

被引：23

作者：

Wang, Deping ^{[1
]}

Kuang, Daizhi ^{[1
]}

Zhang, Fuxing ^{[1
]}

Liu, Yang ^{[1
]}

Ning, Shunhua ^{[1
]}

机构：

[1] Hengyang Normal Univ, Dept Chem & Mat Sci, Hengyang 421008, Hunan, Peoples R China

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 51期

基金：

中国国家自然科学基金;

关键词：

Ligand-free; N-arylation; Cu-catalyzed; Heteroarylamines; Ullmann reaction; EMPLOYING AQUEOUS AMMONIA; CROSS-COUPLING REACTIONS; PHOSPHINE OXIDE LIGAND; ARYL HALIDES; C-N; ROOM-TEMPERATURE; AMINO-ACIDS; CONTAINING HETEROCYCLES; NITROGEN NUCLEOPHILES; ALIPHATIC-AMINES;

D O I：

10.1016/j.tetlet.2014.11.002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol for ligand-free Cu-catalyzed N-arylation of heteroarylamines has been developed. With the use of 1% CuI, a wide range of aryl iodides and bromides coupled with heteroarylamines to afford the corresponding products in high yields. Further, this protocol is particularly suitable for reactions of the most hindered aryl iodides with 2-aminopyridines. (C) 2014 Elsevier Ltd. All rights reserved.

引用

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页码：7121 / 7123

页数：3

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