Ibrutinib in Refractory or Relapsing Primary Central Nervous System Lymphoma: A Systematic Review

被引：8

作者：

Nepal, Gaurav ^{[1
]}

Khurana, Mahika ^{[2
]}

Bucheli, Domenica Herrera ^{[3
]}

Bhandari, Siddhartha ^{[1
]}

Joshi, Utsav ^{[4
]}

Bhagat, Riwaj ^{[5
]}

Rehrig, Jessica Holly ^{[6
]}

Pudasainee, Prasun ^{[7
]}

Shing, Yow Ka ^{[8
]}

Ortiz, Juan Fernando ^{[9
]}

Ojha, Rajeev ^{[10
]}

Gajurel, Bikram Prasad ^{[10
]}

Quinonez, Jonathan ^{[11
,12
]}

Ruxmohan, Samir ^{[11
]}

Albert, Trevine ^{[12
]}

Licata, Steven ^{[12
]}

Stien, Joel ^{[12
]}

机构：

[1] Tribhuvan Univ, Dept Internal Med, Inst Med, Kathmandu 44600, Nepal

[2] Berkeley Publ Hlth Div, Dept Publ Hlth, Berkeley, CA 94704 USA

[3] Univ Int Ecuador, Dept Med, Loja 110150, Ecuador

[4] Rochester Gen Hosp, Dept Internal Med, Rochester, NY 14621 USA

[5] Boston Univ, Dept Neurol, Med Ctr, Boston, MA 02118 USA

[6] North Shore Univ Hosp, Dept Neurol, Manhasset, NY 11030 USA

[7] AMITA Hlth St Francis Hosp, Dept Internal Med, Evanston, IL 60202 USA

[8] Natl Univ Singapore Hosp, Dept Internal Med, Singapore 119074, Singapore

[9] Calif Inst Behav Neurosci & Psychol, Dept Neurol, Fairfield, CA 94534 USA

[10] Tribhuvan Univ Teaching Hosp, Dept Neurol, Kathmandu 44600, Nepal

[11] Larkin Community Hosp, Dept Neurol, South Miami, FL 33143 USA

[12] Larkin Community Hosp, Dept Osteopath Neuromuscular Med, Miami, FL 33143 USA

来源：

NEUROLOGY INTERNATIONAL | 2022年 / 14卷 / 01期

关键词：

ibrutinib; BTK; Bruton tyrosine kinase inhibitor; PCNSL; primary central nervous system lymphoma; lymphoma; CNS LYMPHOMA; RADIOTHERAPY; MONOTHERAPY; OUTCOMES;

D O I：

10.3390/neurolint14010009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Primary Central Nervous System Lymphoma (PCNSL) is a rare variant of Non-Hodgkin Lymphoma (NHL) representing 1-2% of all NHL cases. PCNSL is defined as a lymphoma that occurs in the brain, spinal cord, leptomeninges, or eyes. Efforts to treat PCNSL by traditional chemotherapy and radiotherapy have generally been unsuccessful as a significant proportion of patients have frequent relapses or are refractory to treatment. The prognosis of patients with Refractory or Relapsed (R/R) PCNSL is abysmal. The optimal treatment for R/R PCNSL is poorly defined as there are only a limited number of studies in this setting. Several studies have recently shown that ibrutinib, a Bruton tyrosine kinase (BTK) inhibitor, has promising results in the treatment of R/R PCNSL. However, these are preliminary studies with a limited sample size. In this systematic review, we explored and critically appraised the evidence about the efficacy of the novel agent ibrutinib in treating R/R PCNSL.

引用

页码：99 / 108

页数：10

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