Cytotoxic gephyromycins from the Streptomyces sp SS13I

被引：22

作者：

Jiang, Yong Jun ^{[1
]}

Gan, Li-She ^{[2
]}

Ding, Wan-Jing ^{[1
]}

Chen, Zhe ^{[3
]}

Ma, Zhong-Jun ^{[1
]}

机构：

[1] Zhejiang Univ, Inst Marine Biol, Ocean Coll, Zhoushan 316021, Peoples R China

[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[3] Zhejiang Chinese Med Univ, Zhejiang Hosp Tradit Chinese Med, Zhejiang Key Lab Castrointestinal Pathophysiol, Hangzhou 310006, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Angucyclinones; Gephyromycins; X-ray diffraction; ECD calculations; Cytotoxicity; BROMODOMAIN; PROTEINS;

D O I：

10.1016/j.tetlet.2017.08.035

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new gephyromycins (1-2), belonging to angucyclinones, were identified from Streptomyces sp. SS13I. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and the structure of 1 was further elucidated by X-ray diffraction data. The absolute configurations of compounds 1-2 were evidenced by ECD calculations. To our best knowledge, Compounds 1-2 were the second reported gephyromycin-type angucyclinones. Compound 2 exhibited significant cytotoxicity against PC3 cell lines with IC50 values of 1.38 +/- 0.47 mu M. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：3747 / 3750

页数：4

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