Cytotoxic gephyromycins from the Streptomyces sp SS13I

被引：19
|
作者：
Jiang, Yong Jun [1 ]
Gan, Li-She [2 ]
Ding, Wan-Jing [1 ]
Chen, Zhe [3 ]
Ma, Zhong-Jun [1 ]
机构：
[1] Zhejiang Univ, Inst Marine Biol, Ocean Coll, Zhoushan 316021, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Zhejiang Hosp Tradit Chinese Med, Zhejiang Key Lab Castrointestinal Pathophysiol, Hangzhou 310006, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 38期
基金：
中国国家自然科学基金;
关键词：
Angucyclinones; Gephyromycins; X-ray diffraction; ECD calculations; Cytotoxicity; BROMODOMAIN; PROTEINS;
D O I：
10.1016/j.tetlet.2017.08.035
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new gephyromycins (1-2), belonging to angucyclinones, were identified from Streptomyces sp. SS13I. Their structures were elucidated by analysis of HRESIMS, 1D and 2D NMR spectroscopic data, and the structure of 1 was further elucidated by X-ray diffraction data. The absolute configurations of compounds 1-2 were evidenced by ECD calculations. To our best knowledge, Compounds 1-2 were the second reported gephyromycin-type angucyclinones. Compound 2 exhibited significant cytotoxicity against PC3 cell lines with IC50 values of 1.38 +/- 0.47 mu M. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3747 / 3750
页数：4
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