CLAZAKIZUMAB (CLZ, ANTI-IL-6) AND TOCILIZUMAB (TCZ, ANTI-IL-6 RECEPTOR) DIFFERENTIALLY AFFECT IL-6/IL-6R SIGNALING BY MODULATING SOLUBLE IL-6R & GP130 IN PATIENTS TREATED FOR CHRONIC ANTIBODY-MEDIATED REJECTION (CABMR)

被引：0
|
作者：
Shin, Bongha [1 ]
Vo, Ashley [1 ]
Ge, Shili [1 ]
Petrosyan, Anna [1 ]
Ammerman, Noriko [1 ]
Jordan, Stanley [1 ]
Toyoda, Mieko [1 ]
机构：
[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA
来源：
TRANSPLANT INTERNATIONAL | 2019年 / 32卷
关键词：
D O I：
暂无
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
LBP023
引用
收藏
页码：410 / 410
页数：1
相关论文
共 50 条
  • [41] Blockade of IL-6 signaling via soluble IL-6R is superior to global IL-6 blockade by antibodies in models of inflammation and septic shock
    Rose-John, Stefan
    Barkhausen, Tanja
    Adam, Nina
    Chalaris, Athena
    Waetzig, Georg
    Scheller, Juergen
    CYTOKINE, 2010, 52 (1-2) : 100 - 101
  • [42] Reduction of astrocytic gliosis conferred by bone marrow stromal cells via inhibition of IL-6/IL-6R/gp130
    Gao, Qi
    Qu, Runjiang
    Li, Yi
    Shen, Lihong
    Chopp, Michael
    STROKE, 2007, 38 (02) : 553 - 553
  • [43] Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
    Kazuyuki Yoshizaki
    Norihiro Nishimoto
    Masahiro Mihara
    Tadamitsu Kishimoto
    Springer Seminars in Immunopathology, 1998, 20 : 247 - 259
  • [44] The association of IL-6 and IL-6R gene polymorphisms with chronic periodontitis in a Chinese population
    Zhang, H-Y
    Feng, L.
    Wu, H.
    Xie, X-D
    ORAL DISEASES, 2014, 20 (01) : 69 - 75
  • [45] Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody
    Yoshizaki, K
    Nishimoto, N
    Mihara, M
    Kishimoto, T
    SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1998, 20 (1-2): : 247 - 259
  • [46] Anti-IL-6 receptor antibody treatment improves interstitial lung diseases in IL-6 transgenic mice
    Sugamata, Y
    Nakahara, H
    Katsume, A
    Sugimoto, M
    Yoshizaki, K
    Nishimoto, N
    JOURNAL OF LEUKOCYTE BIOLOGY, 2001, : 81 - 81
  • [47] Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses
    Müller-Newen, G
    Küster, A
    Hemmann, U
    Keul, R
    Horsten, U
    Martens, A
    Graeve, L
    Wijdenes, J
    Heinrich, PC
    JOURNAL OF IMMUNOLOGY, 1998, 161 (11): : 6347 - 6355
  • [48] Activation of gp130 by IL-6 soluble IL-6 receptor induces neuronal differentiation
    März, P
    Herget, T
    Lang, E
    Otten, U
    Rose-John, S
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (12) : 2765 - 2773
  • [49] Anti-IL-6 Antibody Clazakizumab Is More Potent Than Tocilizumab In Blocking In Vitro and Ex Vivo IL-6-Induced Functions
    Zhao, Q.
    Pang, J.
    Shuster, D.
    Hung, C.
    Baglino, S.
    Dodge, R.
    Sun, H.
    Trigona, W.
    Salter-Cid, L.
    ARTHRITIS AND RHEUMATISM, 2013, 65 : S1020 - S1020
  • [50] DNA microarray analysis of SLE related genes that respond to IL-6 blockade with tocilizumab, an anti-IL-6 receptor monoclonal antibody
    Ishikawa, S.
    Aoki, C.
    Yoshio, N.
    Nakahara, H.
    Saito, K.
    Tanaka, Y.
    Kishimoto, T.
    Nishimoto, N.
    ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 : 474 - 474
12345