Synthesis and Antiviral Activity of Novel Thieno[2,3-d]pyrimidine Hydrazones and Their C-Nucleosides

被引：17

作者：

Khattab, R. R. ^{[1
]}

Hassan, A. A. ^{[2
,3
]}

Kutkat, O. M. ^{[4
]}

Abuzeid, K. M. ^{[1
]}

Hassan, N. A. ^{[1
,3
]}

机构：

[1] Natl Res Ctr, Photochem Dept, Cairo 12622, Egypt

[2] Univ Suez, Fac Sci, Chem Dept, Suez, Egypt

[3] Shaqra Univ, Coll Pharm, Pharmaceut Sci Dept, Riyadh, Saudi Arabia

[4] Natl Res Ctr, Ctr Sci Excellence Influenza Virus, Cairo 12311, Egypt

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期

关键词：

triazolo derivatives; monosaccharides; sugar hydrazones; C-nucleosides; antiviral activity; BIOLOGICAL EVALUATION; DERIVATIVES; ANTICANCER; THIENOPYRIMIDINES;

D O I：

10.1134/S1070363219080267

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A hydrazinylthienopyrimidine derivative reacted with a number of monosaccharides in the presence of a catalytic amount of acetic acid giving the corresponding sugar hydrazones, that undergo oxidative cyclization under the action of ferric chloride with formation of triazolo derivatives. Structures of the products have been elucidated from IR, H-1, and C-13 NMR data. Antiviral activity of the newly synthesized compounds is tested against influenza virus H5N1.

引用

页码：1707 / 1717

页数：11

共 50 条

[41] SYNTHESIS OF THIENO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR FLUORESCENT AND BIOLOGICAL PROPERTIES
SABNIS, RW
RANGNEKAR, DW
INDIAN JOURNAL OF TECHNOLOGY, 1990, 28 (02): : 54 - 58
[42] HETEROCYCLIC SYNTHESIS WITH NITRILES - A NOVEL SYNTHESIS OF SOME THIOPHENE AND THIENO[2,3-D]PYRIMIDINE DERIVATIVES .2.
ABDELRAZEK, FM
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1989, 44 (04): : 488 - 492
[43] Synthesis and Anticancer Activity of Functionalized Thieno[2,3-d]pyrimidine Compounds and Their Triazinyl and Tetrazinyl Derivatives
Dalia Ahmed A. Walaa I. El-Sofany
Asma M. Othman
El-Manawaty A. Mahran
Wael A. May
Russian Journal of Bioorganic Chemistry, 2020, 46 : 393 - 402
[44] Synthesis and Anticancer Activity of Functionalized Thieno[2,3-d]pyrimidine Compounds and Their Triazinyl and Tetrazinyl Derivatives
El-Sofany, Walaa I.
Othman, Dalia Ahmed A.
Mahran, Asma M.
May, El-Manawaty A.
El-Sayed, Wael A.
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2020, 46 (03) : 393 - 402
[45] Synthesis of polyfunctionally substituted thiophene, thieno[2,3-b]pyridine and thieno[2,3-d]pyrimidine derivatives
Wardakhan, WW
Shams, HZ
Moustafa, HE
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (08) : 1815 - 1827
[46] STERIC FIXATION OF BROMOVINYLURACIL - SYNTHESIS OF FURO[2,3-D]PYRIMIDINE NUCLEOSIDES
EGER, K
JALALIAN, M
SCHMIDT, M
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1995, 32 (01) : 211 - 218
[47] SYNTHESIS OF FURO[3,2-D]PYRIMIDINE C-NUCLEOSIDES
BHATTACHARYA, BK
LIM, MI
OTTER, BA
KLEIN, RS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1986, 191 : 5 - CARB
[48] Synthesis of thieno[2,3-d]pyrimidines, thieno[2,3-d]triazinones and thieno[2,3-e]diazepinones of anticipated anti-cancer activity
Kandeel, M. M.
Mounir, Ashraf A.
Refaat, Hanan M.
Kassab, Asmaa E.
JOURNAL OF CHEMICAL RESEARCH, 2012, (02) : 105 - 110
[49] Bicyclic furano-, pyrrolo-, and thiopheno[2,3-d] derivatives of pyrimidine nucleosides: Synthesis and antiviral properties
M. A. Ivanov
L. A. Aleksandrova
Russian Journal of Bioorganic Chemistry, 2013, 39 : 22 - 39
[50] SYNTHESIS AND ANTIVIRAL ACTIVITY OF SOME ACYCLIC AND C-ACYCLIC PYRROLO[2,3-D]PYRIMIDINE NUCLEOSIDE ANALOGS
BENNETT, SM
NGUYENBA, N
OGILVIE, KK
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (08) : 2162 - 2173

← 1 2 3 4 5 →