Synthesis, structure, and in vitro anti-lung cancer activity on an In-based nanoscale coordination polymer

Here, a new indium (In)-based coordination polymer [In(hip)](DMF)(2) (H2O)(3) (1, DMF=N,N-dimethyl-formamide) was successfully prepared by a solvothermal reaction of In(NO3)(3)center dot 6H(2)O and 5-hydroxyisophthalic acid (H(3)hip) in a mixed solvent of DMF and H2O with the presence of NaCl as a template. Complex 1 was characterized by elemental analysis (EA), single-crystal X-ray crystallography, and powder X-ray diffraction (PXRD), and the results reveal that complex 1 shows a two-dimensional (2D) grid-like network with considerable solvent accessible volume that was generated from the packing of the 2D layers via the AB pattern. Furthermore, complex 1 could be downsized into nanoscale particles with the aid of polyvinylpyrrolidone (PVP). In addition, the anticancer activities of 1 and the nanoscale 1 were probed via the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay.