Antibacterial and anti-inflammatory agents that target endotoxin

被引：97
|
作者：
Wyckoff, TJO [1 ]
Raetz, CRH [1 ]
Jackman, JE [1 ]
机构：
[1] Duke Univ, Dept Biochem, Med Ctr, Durham, NC 27710 USA
来源：
TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 04期
关键词：
D O I：
10.1016/S0966-842X(98)01230-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in. Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.
引用
收藏
页码：154 / 159
页数：6
相关论文
共 50 条
  • [31] Anti-inflammatory effects of the antibiotics ceftazidime and tobramycin in porcine endotoxin shock: are they really anti-inflammatory?
    Wiedermann, FJ
    CRITICAL CARE, 2004, 8 (02): : 140 - 140
  • [32] Synthesis and biological evaluation studies of novel quinazolinone derivatives as antibacterial and anti-inflammatory agents
    Zayed, Mohamed F.
    Hassan, Memy H.
    SAUDI PHARMACEUTICAL JOURNAL, 2014, 22 (02) : 157 - 162
  • [33] Evaluation of newly synthesized quinazolinone derivatives of hydrazones as potent anti-inflammatory and antibacterial agents
    Bhavna Kandpal
    Jyotsna Meshram
    Ipsita Mohanram
    Ambareen Shaikh
    Medicinal Chemistry Research, 2015, 24 : 1419 - 1426
  • [34] Evaluation of newly synthesized quinazolinone derivatives of hydrazones as potent anti-inflammatory and antibacterial agents
    Kandpal, Bhavna
    Meshram, Jyotsna
    Mohanram, Ipsita
    Shaikh, Ambareen
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (04) : 1419 - 1426
  • [35] The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target
    K. Mazumdar
    S. G. Dastidar
    J. H. Park
    N. K. Dutta
    European Journal of Clinical Microbiology & Infectious Diseases, 2009, 28
  • [36] The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target
    Mazumdar, K.
    Dastidar, S. G.
    Park, J. H.
    Dutta, N. K.
    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2009, 28 (08) : 881 - 891
  • [37] Anti-Inflammatory Drugs as Anticancer Agents
    Zappavigna, Silvia
    Cossu, Alessia Maria
    Grimaldi, Anna
    Bocchetti, Marco
    Ferraro, Giuseppe Andrea
    Nicoletti, Giovanni Francesco
    Filosa, Rosanna
    Caraglia, Michele
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (07)
  • [38] Discovery of new anti-inflammatory agents
    Fülöp, F
    Lázár, L
    Szakonyi, Z
    Pihlavisto, M
    Alaranta, S
    Vainio, PJ
    Juhakoski, A
    Marjamäki, A
    Smith, DJ
    PURE AND APPLIED CHEMISTRY, 2004, 76 (05) : 965 - 972
  • [39] LATENT TUBERCULOSIS AND ANTI-INFLAMMATORY AGENTS
    BRENNAN, M
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 1982, 126 (01) : 21 - 21
  • [40] Anti-inflammatory properties of anesthetic agents
    Fernanda Ferreira Cruz
    Patricia Rieken Macedo Rocco
    Paolo Pelosi
    Critical Care, 21
12345