Antibacterial and anti-inflammatory agents that target endotoxin

被引：97

作者：

Wyckoff, TJO ^{[1
]}

Raetz, CRH ^{[1
]}

Jackman, JE ^{[1
]}

机构：

[1] Duke Univ, Dept Biochem, Med Ctr, Durham, NC 27710 USA

来源：

TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 04期

关键词：

D O I：

10.1016/S0966-842X(98)01230-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibiotic-resistant bacterial infections are a major clinical problem. Lipid A, the active part of lipopolysaccharide endotoxins in. Gram-negative bacteria, is an intriguing target for new antibacterial and anti-inflammatory agents. Inhibition of lipid A biosynthesis kills most Gram-negative bacteria, increases bacterial permeability to antibiotics and decreases endotoxin production.

引用

页码：154 / 159

页数：6

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