Clinical trial designs for targeted agents

被引：10
|
作者：
Ma, BBY
Britten, CD
Siu, LL
机构：
[1] Univ Toronto, Princess Margaret Hosp, Hlth Network, Dept Med Oncol, Toronto, ON M5G 2M9, Canada
[2] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA
来源：
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2002年 / 16卷 / 05期
关键词：
D O I：
10.1016/S0889-8588(02)00045-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The unique properties of contemporary targeted drugs pose major challenges for the development of anticancer therapy, necessitating modification of traditional clinical trial designs. This article discusses some of the strategies employed to evaluate these agents in the phase I to 111 setting, citing examples of some recently tested targeted agents to illustrate the advantages and disadvantages of various approaches.
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页码：1287 / +
页数：20
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