A High Ki67/BCL2 Index Could Predict Lower Disease- Free and Overall Survival in Intestinal-Type Gastric Cancer

被引：15

作者：

Min, Kyueng-Whan ^{[1
]}

Kim, Dong-Hoon ^{[2
]}

Son, Byoung Kwan ^{[3
]}

Kim, Dong Hyun ^{[2
]}

Kim, Eun-Kyung ^{[4
]}

Seo, Jinwon ^{[5
]}

Ahn, Sang Bong ^{[3
]}

Jo, Yun Ju ^{[3
]}

Park, Young Sook ^{[3
]}

Ha, Junghoon ^{[3
]}

机构：

[1] Hanyang Univ, Coll Med, Guri Hosp, Dept Pathol, Guri, South Korea

[2] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pathol, Seoul, South Korea

[3] Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Internal Med, 68 Hangeulbiseok Ro, Seoul 01830, South Korea

[4] Eulji Univ, Sch Med, Eulji Gen Hosp, Dept Pathol, Seoul, South Korea

[5] Hallym Univ, Coll Med, Sacred Heart Hosp, Dept Pathol, Anyang, South Korea

来源：

EUROPEAN SURGICAL RESEARCH | 2017年 / 58卷 / 3-4期

关键词：

bcl-2 homologous antagonist/killer protein; Ki67; antigen; Prognosis; Adenocarcinoma; Stomach; Human; BCL-2; EXPRESSION; CELL-PROLIFERATION; PATIENT SURVIVAL; KI-67; POOR-PROGNOSIS; BREAST-CANCER; KI67; IMMUNOREACTIVITY; CLASSIFICATION; CARCINOMAS;

D O I：

10.1159/000448945

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The heterogeneity of gastric cancer makes the identification of potential prognostic indicators particularly important. The Ki67 and BCL2 proteins are known prognostic markers for different types of cancer. Ki67 is associated with cell proliferation, whereas BCL2 has antiproliferative roles. A combined marker based on these opposite functions might provide improved prognostic information in gastric cancer. Method: Ki67 and BCL2 expression was assessed in 276 gastric adenocarcinoma tissue microarrays. A Ki67/BCL2 index based on the relative expression of each protein was divided into low- and high-risk groups using receiver operating characteristic curves. Results: A high Ki67/BCL2 index significantly correlated with advanced stage, recurrence, intestinal type, high histologic grade, and lymphatic and perineural invasion (all p < 0.05). Univariate and multivariate analyses revealed a significant relationship between disease-free or overall survival and the Ki67/BCL2 index in intestinal-type gastric cancer (all p < 0.05). Conclusions: A combined marker using Ki67 and BCL2 could be a useful indicator for predicting survival in patients with intestinal-type gastric cancer. (C) 2017 S. Karger AG, Basel

引用

页码：158 / 168

页数：11

共 21 条

[21] Non-endometrioid and high-grade endometrioid endometrial cancers show DNA fragmentation factor 40 (DFF40) and B-cell lymphoma 2 protein (BCL2) underexpression, which predicts disease-free and overall survival, but not DNA fragmentation factor 45 (DFF45) underexpression
Tomasz Banas
Kazimierz Pitynski
Krzysztof Okon
Aleksandra Winiarska
BMC Cancer, 18

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