A Bacillus anthracis system for acquisition of heme-bound iron

被引：0
|
作者：
Eremenko, E. I. [1 ]
机构：
[1] Stavropol Plague Control Res Inst, Fed Serv Surveillance Consumer Rights Protect & H, Stavropol 355035, Russia
来源：
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY | 2017年 / 32卷 / 01期
关键词：
hemophores; iron intake; virulence of B. anthracis; SURFACE PROTEIN ISDC; STAPHYLOCOCCUS-AUREUS; HEMOGLOBIN; HEMOPHORE; RECEPTOR;
D O I：
10.3103/S0891416817010037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In Bacillus anthracis, an alternative to the use of chelating agents (siderophores) for acquiring iron consists in using a system of hemophores and transporter proteins for scavenging hemes from hemoglobin and delivering them into the bacterial cell. B. anthracis utilizes the siderophore-mediated mechanism of acquiring iron predominantly at the intracellular stage of its development, with the system of hemophores and transporter proteins being used at the extracellular stage of anthrax infection. The structure, genetic organization, and functions of the system for heme iron acquisition in B. anthracis, understanding of which may facilitate the development of new therapies for anthrax, are discussed.
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页码：1 / 5
页数：5
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