Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development

被引：1382
|
作者：
Ip, YT
Davis, RJ [1 ]
机构：
[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA
[2] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01605 USA
[3] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA
[4] Univ Massachusetts, Sch Med, Dept Biochem & Mol Biol, Worcester, MA 01605 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 02期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0955-0674(98)80143-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The c-Jun amino-terminal kinase (JNK) group of MAP kinases has been identified in mammals and insects. JNK is activated by exposure of cells to cytokines or environmental stress, indicating that this signaling pathway may contribute to inflammatory responses. Genetic and biochemical studies demonstrate that this signaling pathway also regulates cellular proliferation, apoptosis, and tissue morphogenesis. A functional role for JNK is therefore established in both the cellular response to stress and in many normal physiological processes. (C) Current Biology Ltd ISSN 0955-0674.
引用
收藏
页码：205 / 219
页数：15
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