Design and evaluation in mice of a broadly protective meningococcal group B native outer membrane vesicle vaccine

被引：61

作者：

Zollinger, Wendell D. ^{[1
]}

Donets, Mikhail A. ^{[1
]}

Schmiel, Deborah H. ^{[1
]}

Pinto, Valerian B. ^{[1
]}

Labrie, Joseph E., III ^{[1
]}

Moran, Elizabeth E. ^{[1
]}

Brandt, Brenda L. ^{[1
]}

Ionin, Boris ^{[1
]}

Marques, Ryan ^{[1
]}

Wu, Max ^{[1
]}

Chen, Ping ^{[1
]}

Stoddard, Mark B. ^{[1
]}

Keiser, Paul B. ^{[1
]}

机构：

[1] WRAIR, Div Bacterial & Rickettsial Dis, Silver Spring, MD 20910 USA

来源：

VACCINE | 2010年 / 28卷 / 31期

关键词：

Neisseria meningitidis; Vaccine; Vesicles; MENINGITIDIS SEROGROUP-B; LIPOPOLYSACCHARIDE CORE OLIGOSACCHARIDES; SYNERGISTIC BACTERICIDAL ACTIVITY; NEISSERIA-MENINGITIDIS; MONOCLONAL-ANTIBODIES; PROTEIN; IMMUNOGENICITY; DISEASE; POLYSACCHARIDE; CANDIDATE;

D O I：

10.1016/j.vaccine.2010.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A vaccine based on native outer membrane vesicles (NOMV) that has potential to provide safe, broad based protection against group B strains of Neisseria meningitidis has been developed. Three antigenically diverse group B strains of N. meningitidis were chosen and genetically modified to improve safety and expression of desirable antigens. Safety was enhanced by disabling three genes: synX, IpxL1, and IgtA. The vaccine strains were genetically configured to have three sets of antigens each with potential to induce protective antibodies against a wide range of group B strains. Preliminary immunogenicity studies with combined NOMV from the three strains confirmed the capacity of the vaccine to induce a broad based bactericidal antibody response. Analysis of the bactericidal activity indicated that antibodies to the LOS were responsible for a major portion of the bactericidal activity and that these antibodies may enhance the bactericidal activity of anti-protein antibodies. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5057 / 5067

页数：11

共 50 条

[41] FetA Antibodies Induced by an Outer Membrane Vesicle Vaccine Derived from a Serogroup B Meningococcal Isolate with Constitutive FetA Expression
Sanders, Holly
Norheim, Gunnstein
Chan, Hannah
Dold, Christina
Vipond, Caroline
Derrick, Jeremy P.
Pollard, Andrew J.
Maiden, Martin C. J.
Feavers, Ian M.
PLOS ONE, 2015, 10 (10):
[42] Human B- and T-cell responses after immunization with a hexavalent PorA meningococcal outer membrane vesicle vaccine
vanderVoort, ER
vanDijken, H
Kuipers, B
vanderBiezen, J
vanderLey, P
Meylis, J
Claassen, I
Poolman, J
INFECTION AND IMMUNITY, 1997, 65 (12) : 5184 - 5190
[43] Human B Cell Responses to Dominant and Subdominant Antigens Induced by a Meningococcal Outer Membrane Vesicle Vaccine in a Phase I Trial
Rollier, Christine S.
Dold, Christina
Marsay, Leanne
Linder, Aline
Green, Christopher A.
Sadarangani, Manish
Norheim, Gunnstein
Derrick, Jeremy P.
Feavers, Ian M.
Maiden, Martin C. J.
Pollard, Andrew J.
MSPHERE, 2022, 7 (01)
[44] Evaluation of a Burkholderia pseudomallei Outer Membrane Vesicle Vaccine in Nonhuman Primates
Petersen, Hailey
Nieves, Wildaliz
Russell-Lodrigue, Kasi
Roy, Chad J.
Morici, Lisa A.
7TH VACCINE & ISV ANNUAL GLOBAL CONGRESS, 2014, 8 : 38 - 42
[45] Prothrombotic and proinflammatory effects of meningococcal group B outer membrane vesicles
Mirlashari, MR
Hoiby, EA
Holst, J
Lyberg, T
THROMBOSIS AND HAEMOSTASIS, 1999, : 459 - 459
[46] Improved Production Process for Native Outer Membrane Vesicle Vaccine against Neisseria meningitidis
van de Waterbeemd, Bas
Zomer, Gijsbert
Kaaijk, Patricia
Ruiterkamp, Nicole
Wijffels, Rene H.
van den Dobbelsteen, Germie P. J. M.
van der Pol, Leo A.
PLOS ONE, 2013, 8 (05):
[47] Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles
Bai, Xilian
Findlow, Jamie
Borrow, Ray
EXPERT OPINION ON BIOLOGICAL THERAPY, 2011, 11 (07) : 969 - 985
[48] A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial
Marsay, L.
Dold, C.
Green, C. A.
Rollier, C. S.
Norheim, G.
Sadarangani, M.
Shanyinde, M.
Brehony, C.
Thompson, A. J.
Sanders, H.
Chan, H.
Haworth, K.
Derrick, J. P.
Feavers, I. M.
Maiden, M. C.
Pollard, A. J.
JOURNAL OF INFECTION, 2015, 71 (03) : 326 - 337
[49] Characterization of the Protein Content of a Meningococcal Outer Membrane Vesicle Vaccine by Polyacrylamide Gel Electrophoresis and Mass Spectrometry
Vipond, Caroline
Wheeler, Jun X.
Jones, Christopher
Feavers, Ian M.
Suker, Janet
HUMAN VACCINES, 2005, 1 (02): : 80 - 84
[50] A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity
Dowling, David J.
Sanders, Holly
Cheng, Wing Ki
Joshi, Sweta
Brightman, Spencer
Bergelson, Ilana
Pietrasanta, Carlo
van Haren, Simon D.
van Amsterdam, Sandra
Fernandez, Jeffrey
van den Dobbelsteen, Germie P. J. M.
Levy, Ofer
FRONTIERS IN IMMUNOLOGY, 2016, 7

← 1 2 3 4 5 →