Proportion of osteoporotic post-menopausal women at increased risk for upper GI adverse events associated with bisphosphonate therapy

被引:0
|
作者
Levine, MAH
Grootendorst, P
机构
[1] McMaster Univ, Father Sean OSullivan Res Ctr, Ctr Evaluat Med, Hamilton, ON L8S 4L8, Canada
[2] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4L8, Canada
关键词
bisphosphonate; postmarketing surveillance; gastroesophagous;
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background - The bisphosphonate alendronate has been associated with higher rates of adverse oesophageal effects when used in the community setting compared to what was observed in the clinical trials. Patients with a history of gastroesophageal problems or who are concurrently using an NSAID therapy may be at increased risk for the gastroesophageal problems associated with alendronate use. This study assesses the proportion of post-menopausal women in the community with osteoporosis that are at increased risk for gastroesophageal adverse effects associated with alendronate. Methods - The administrative database for the Quebec government drug benefit program was used to identify a cohort of 5400 post menopausal women aged 65 years or older who were using the bisphosphonate etidronate for the treatment of osteoporosis. Patients were evaluated for the presence of either risk factor, chronic GI drug therapy use (a marker for prior gastroesophageal problems) or chronic NSAID use. Findings - 31% of women taking etidronate were also chronically using GI drug therapies and 50% were using NSAIDs; 18% of the women were using all three drugs. Interpretation - Many osteoporosis patients in the community setting who are candidates for bisphosphonate therapy might be considered at increased risk for alendronate's gastroesophageal adverse effects. This may account for differences in pre-marketing and postmarketing event rates. Copyright (C) 2000 John Wiley & Sons, Ltd.
引用
收藏
页码:367 / 370
页数:4
相关论文
共 50 条
  • [31] Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women
    Taboulet, J
    Frenkian, M
    Frendo, JL
    Feingold, N
    Jullienne, A
    de Vernejoul, MC
    HUMAN MOLECULAR GENETICS, 1998, 7 (13) : 2129 - 2133
  • [32] Risk factors for osteoporotic fracture in post-menopausal South Asian women living in Blackburn, United Kingdom
    Mitra, S.
    Foster, P.
    Judd, P.
    Ellahi, B.
    McCann, J. F.
    Lowe, N.
    OSTEOPOROSIS INTERNATIONAL, 2006, 17 : 405 - 405
  • [33] Hormone replacement therapy is associated with improved arterial physiology in healthy post-menopausal women
    McCrohon, JA
    Adams, MR
    McCredie, RJ
    Robinson, J
    Pike, A
    Abbey, M
    Keech, AC
    Celermajer, DS
    CLINICAL ENDOCRINOLOGY, 1996, 45 (04) : 435 - 441
  • [34] Hormone therapy is associated with smaller Achilles tendon diameter in active post-menopausal women
    Cook, J. L.
    Bass, S. L.
    Black, J. E.
    SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2007, 17 (02) : 128 - 132
  • [35] Hormone therapy and the risk for stroke after acute myocardial infarction in post-menopausal women
    Angeja, BG
    Shlipak, MG
    Go, AS
    Johnstone, SC
    Frederick, PD
    Canto, JG
    Barron, HV
    Grady, D
    CIRCULATION, 2001, 104 (17) : 818 - 818
  • [36] ARE DIFFERENCES OF HIP SHAPE RESPONSIBLE FOR INCREASED FEMORAL NECK FRACTURE RISK IN POST-MENOPAUSAL WOMEN?
    Oldroyd, A. G. S.
    Nickkho-Amiry, M.
    Evans, B.
    Greenbank, C.
    Bukhari, M.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 71 : 595 - 595
  • [37] Diet, lifestyle and osteoporotic fracture risk in post-menopausal South Asian women living in Blackburn, UK.
    Mitra, S.
    McCann, J. F.
    Bhojani, I.
    Foster, P. C.
    Judd, P. A.
    Ellahi, B.
    Lowe, N. M.
    PROCEEDINGS OF THE NUTRITION SOCIETY, 2006, 65 : 85A - 85A
  • [38] Potential for bone turnover markers to cost-effectively identify and select post-menopausal osteopenic women at high risk of fracture for bisphosphonate therapy
    Schousboe, J. T.
    Bauer, D. C.
    Nyman, J. A.
    Kane, R. L.
    Melton, L. J.
    Ensrud, K. E.
    OSTEOPOROSIS INTERNATIONAL, 2007, 18 (02) : 201 - 210
  • [39] Potential for bone turnover markers to cost-effectively identify and select post-menopausal osteopenic women at high risk of fracture for bisphosphonate therapy
    J. T. Schousboe
    D. C. Bauer
    J. A. Nyman
    R. L. Kane
    L. J. Melton
    K. E. Ensrud
    Osteoporosis International, 2007, 18 : 201 - 210
  • [40] Hormone Replacement Therapy Is Associated With Decreased Disease Severity and Risk for Surgery in Post-Menopausal Women With Inflammatory Bowel Disease
    Freeman, Morgan
    Graziano, Elliot
    Teigen, Levi
    Shmidt, Eugenia
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2021, 116 : S418 - S419