Enantioselective alkynylation of aldehydes catalyzed by new chiral catalysts

被引：0
|
作者：
Chan, ASC [1 ]
Lu, G
Li, XS
机构：
[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China
来源：
METHODOLOGIES IN ASYMMETRIC CATALYSIS | 2004年 / 880卷
关键词：
D O I：
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中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of amino alcohol ligands of binaphthyl derivatives were synthesized and were found to be effective in the enantioselective alkynylation of aldehydes. A variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols in up to 93% e.e. Chiral catalyst systems by virtue of the cooperation of several chiral ligands were also developed. The alkynylation reaction proceeded smoothly to produce the desired products in up to 99.7% ex.
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页码：103 / 113
页数：11
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