Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands

被引：53
|
作者：
Kang, YF
Wang, R [1 ]
Liu, L
Da, CS
Yan, WJ
Xu, ZQ
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
[2] Lanzhou Univ, Sch Life Sci, Dept Biochem & Mol Biol, Lanzhou 730000, Peoples R China
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 05期
基金：
中国国家自然科学基金;
关键词：
aldehydes; alkynes; oxazolidines; addition; asymmetric catalysis;
D O I：
10.1016/j.tetlet.2004.11.165
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New chiral oxazolidines were conveniently synthesized from natural amino acids in three simple steps with good yields. The use of chiral oxazolidine ligands for the enantioselective alkynylation of aldehydes provides a simple, practical and inexpensive method to generate chiral propargyl alcohols with 85-99% ee. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：863 / 865
页数：3
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