HOLLOW MICRONEEDLE ELECTRODE ARRAYS FOR INTRACELLULAR RECORDING APPLICATIONS

被引：3

作者：

Held, J. ^{[1
]}

Gaspar, J. ^{[1
]}

Koester, P. J. ^{[2
]}

Tautorat, C. ^{[2
]}

Hagner, M. ^{[3
]}

Cismak, A. ^{[4
]}

Heilmann, A. ^{[4
]}

Baumann, W.

Ruther, P. ^{[1
]}

Paul, O. ^{[1
]}

机构：

[1] Univ Freiburg, Dept Microsyst Engn IMTEK, Freiburg, Germany

[2] Univ Rostock, Dept Biophys, D-18055 Rostock, Germany

[3] univ Konstanz, Dept Phys, Constance, Germany

[4] Fraunhofer Inst, Dept Biol Mat & Interfaces, Halle, Germany

来源：

IEEE 22ND INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2009) | 2009年

关键词：

D O I：

10.1109/MEMSYS.2009.4805358

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper reports on the fabrication of hollow microneedle electrodes with fluidic channels arranged in 8x8 arrays. Features of these electrodes include (i) an increased surface area for improved intracellular potential measurements with simultaneous membrane cell poration capabilities, (ii) their potential use in highly parallel patch-clamp applications and (iii) the ability to efficiently inject reagents and extract cytoplasm into and from the cell interior, respectively. Three different fabrication processes to realize hollow microneedle electrode arrays with incorporated microfluidic components, as well as initial experiments with cell cultures, are presented.

引用

页码：220 / 223

页数：4

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