Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

被引：1

作者：

Ricci, Jeremy ^{[1
]}

Min, Dongguk ^{[1
]}

Oh, Miyeon ^{[1
]}

Lim, Hyenchong ^{[1
]}

Chung, Won-Yoon ^{[2
]}

Park, Kwang-Kyun ^{[2
]}

Jung, Mankil ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

[2] Yonsei Univ, Dept Oral Biol, Coll Dent, Seoul 120752, South Korea

来源：

MEDICINAL CHEMISTRY | 2015年 / 11卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Daumone; glycolipid; antiangiogenic activity; synthesis; CAENORHABDITIS-ELEGANS; ANTICANCER ACTIVITY; GLYCOLIPID HYBRIDS; LARVAL DEVELOPMENT; PHEROMONE;

D O I：

10.2174/1573406411666150514100630

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

引用

页码：747 / 752

页数：6

共 50 条

[41] Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives
Oh, S
Jeong, IH
Shin, WS
Lee, S
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (14) : 3683 - 3686
[42] Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents
Bai, Wenjing
Ji, Jianxin
Huang, Qiang
Wei, Wei
TETRAHEDRON LETTERS, 2020, 61 (40)
[43] THE CHORIOALLANTOIC MEMBRANE IN IRRITATION TESTING
LAWRENCE, RS
GROOM, MH
ACKROYD, DM
PARISH, WE
FOOD AND CHEMICAL TOXICOLOGY, 1986, 24 (6-7) : 497 - 502
[44] TISSUE EXPLANTS ON THE CHORIOALLANTOIC MEMBRANE
JOHNSON, P
BUTHALA, DA
MICRON, 1981, 12 (01) : 77 - 78
[45] METAPLASTIC CHANGES IN THE CHORIOALLANTOIC MEMBRANE
MOSCONA, A
TRANSPLANTATION BULLETIN, 1960, 26 (01): : 120 - 124
[46] ANGIOGENESIS IS ASSOCIATED WITH COLLAGENOUS PROTEIN-SYNTHESIS AND DEGRADATION IN THE CHICK CHORIOALLANTOIC MEMBRANE
MISSIRLIS, E
KARAKIULAKIS, G
MARAGOUDAKIS, ME
TISSUE & CELL, 1990, 22 (04): : 419 - 426
[47] Evaluation of antiparasitic, antituberculosis and antiangiogenic activities of 3-aminoquinolin-2-one derivatives
Muscia, Gisela C.
Bollini, Mariela
Bruno, Ana M.
Asis, Silvia E.
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2006, 51 (02): : 859 - 863
[48] Novel Coumarin Derivatives Containing a Triazole Moiety: A Study on Synthesis, Cytotoxicity, Membrane Dysfunction, Apoptosis, Cell Cycle, and Antiangiogenic Effects
Guner, Adem
Bektas, Hakan
Mentese, Emre
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2022, 22 (13) : 2429 - 2438
[49] Antioxidant and antiangiogenic activities of propolis
Kumazawa, Shigenori
Ohta, Toshiro
Kaji, Kazuhiko
Nakayama, Tsutomu
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, 127 : 16 - 18
[50] Synthesis of 5-amino-1,3-dihydro-1,3-dioxo-isoindole-2-propanoic acid derivatives and their Antiangiogenic activities
Wu, Bei
Yang, Da-Cheng
Shen, Yi
Deng, Yong
Zhong, Yu-Gu
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2007, 27 (09) : 1110 - 1115

← 1 2 3 4 5 →