A bispecific T-cell engager antibody (BiTE) against TAG-72/CD3 for targeted cancer immunotherapy

被引：0
|
作者：
Khambati, Fatema [1 ]
Soliman, Hatem [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA
来源：
CANCER RESEARCH | 2019年 / 79卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2019-2395
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
2395
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
    Yang, Xiao-mei
    Lin, Xuan-dong
    Shi, Wei
    Xie, Shen-xia
    Huang, Xia-ning
    Yin, Shi-hua
    Jiang, Xiao-bing
    Hammock, Bruce D.
    Xu, Zhi Ping
    Lu, Xiao-ling
    SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 8 (01)
  • [22] Nanobody-based bispecific T-cell engager (Nb-BiTE): a new platform for enhanced T-cell immunotherapy
    Xiao-mei Yang
    Xuan-dong Lin
    Wei Shi
    Shen-xia Xie
    Xia-ning Huang
    Shi-hua Yin
    Xiao-bing Jiang
    Bruce D. Hammock
    Zhi Ping Xu
    Xiao-ling Lu
    Signal Transduction and Targeted Therapy, 8
  • [23] Microenvironment-responsive anti-PD-L1 x CD3 bispecific T-cell engager for solid tumor immunotherapy
    Liu, Dingkang
    Bao, Lichen
    Zhu, Haichao
    Yue, Yali
    Tian, Jing
    Gao, Xiangdong
    Yin, Jun
    JOURNAL OF CONTROLLED RELEASE, 2023, 354 : 606 - 614
  • [24] Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
    Mikami, Hirofumi
    Feng, Shu
    Matsuda, Yutaka
    Ishii, Shinya
    Naoi, Sotaro
    Azuma, Yumiko
    Nagano, Hiroaki
    Asanuma, Kentaro
    Kayukawa, Yoko
    Tsunenari, Toshiaki
    Kamikawaji, Shogo
    Iwabuchi, Ryutaro
    Shinozuka, Junko
    Yamazaki, Masaki
    Kuroi, Haruka
    Ho, Samantha Shu Wen
    Gan, Siok Wan
    Chichili, Priyanka
    Pang, Chai Ling
    Yeo, Chiew Ying
    Shimizu, Shun
    Hironiwa, Naoka
    Kinoshita, Yasuko
    Shimizu, Yuichiro
    Sakamoto, Akihisa
    Muraoka, Masaru
    Takahashi, Noriyuki
    Kawa, Tatsuya
    Shiraiwa, Hirotake
    Mimoto, Futa
    Kashima, Kenji
    Kamata-Sakurai, Mika
    Ishikawa, Shumpei
    Aburatani, Hiroyuki
    Kitazawa, Takehisa
    Igawa, Tomoyuki
    CANCER IMMUNOLOGY RESEARCH, 2024, 12 (06) : 719 - 730
  • [25] Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy
    McCue, Amelia C.
    Demarest, Stephen J.
    Froning, Karen J.
    Hickey, Michael J.
    Antonysamy, Stephen
    Kuhlman, Brian
    MABS, 2024, 16 (01)
  • [26] Generalizable systems pharmacology model of bispecific T-cell engager (BiTE®) antibody constructs: case study of blinatumomab (CD19/CD3) in non-Hodgkin lymphoma (NHL) patients
    Chudasama, Vaishali L.
    Harrold, John M.
    Dos Santos, Cedric
    Rock, Dan
    Kischel, Roman
    Klinger, Matthias
    Melhem, Murad
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2018, 45 : S126 - S127
  • [27] Nonshrinkable Thermosensitive Hydrogels Combined with Bispecific Anti-PSMA/CD3 T-Cell Engager for Effective Against Tumors in Mice Model
    Wei, Pu-Sheng
    Chou, Po-Yu
    Hsu, Hao-Yi
    Chen, Michael
    Chen, Yi-Jou
    Tsai, Tung-Han
    Wen, Bang-Yu
    Sheu, Ming-Thau
    Chuang, Kuo-Hsiang
    Lin, Hong-Liang
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2025, 20 : 3083 - 3111
  • [28] A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma
    Xiong, Mengshang
    Liu, Ruoqi
    Lei, Xiaomin
    Fan, Dongmei
    Lin, Fangzhen
    Hao, Wei
    Yuan, Xiangfei
    Yang, Yuanyuan
    Zhang, Xiaolong
    Ye, Zhou
    Lu, Yang
    Zhang, Yanjun
    Wang, Jianxiang
    Xiong, Dongsheng
    JOURNAL OF IMMUNOTHERAPY, 2022, 45 (02) : 78 - 88
  • [29] T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
    Middelburg, Jim
    Sluijter, Marjolein
    Schaap, Gaby
    Goynuk, Busra
    Lloyd, Katy
    Ovcinnikovs, Vitalijs
    Zom, Gijs G.
    Marijnissen, Renoud J.
    Groeneveldt, Christianne
    Griffioen, Lisa
    Sandker, Gerwin G. W.
    Heskamp, Sandra
    van der Burg, Sjoerd H.
    Arakelian, Tsolere
    Ossendorp, Ferry
    Arens, Ramon
    Schuurman, Janine
    Kemper, Kristel
    van Hall, Thorbald
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [30] T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors
    Jim Middelburg
    Marjolein Sluijter
    Gaby Schaap
    Büşra Göynük
    Katy Lloyd
    Vitalijs Ovcinnikovs
    Gijs G. Zom
    Renoud J. Marijnissen
    Christianne Groeneveldt
    Lisa Griffioen
    Gerwin G. W. Sandker
    Sandra Heskamp
    Sjoerd H. van der Burg
    Tsolere Arakelian
    Ferry Ossendorp
    Ramon Arens
    Janine Schuurman
    Kristel Kemper
    Thorbald van Hall
    Nature Communications, 15
12345