Novel N-hydroxamic acid hydrazide inhibitors of TNF-α synthesis

被引：0
|
作者：
机构：
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2000年 / 10卷 / 10期
关键词：
ADAM-17; rheumatoid arthritis; TACE; TNF-alpha; TNF synthesis inhibitor;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two patent applications claim novel N-hydroxamic acid hydrazide inhibitors of TNF-alpha synthesis, that act via inhibition of the TNF-alpha-converting enzyme (TACE or ADAM-17). The hydrazides are claimed to be useful in the treatment of inflammatory diseases such as rheumatoid arthritis. The claimed sulphonylhydrazide and cyclic hydrazide derivatives both display comparable in vitro potency to Roche's clinical development lead Ro 32-7315.
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页码：1617 / 1621
页数：5
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