Implications of cancer evolution for drug development

被引：27

作者：

Turajlic, Samra ^{[1
,2
,3
]}

Swanton, Charles ^{[1
,4
]}

机构：

[1] Francis Crick Inst, Translat Canc Therapeut Lab, 1 Midland Rd, London NW1 1AT, England

[2] Royal Marsden Hosp, Renal Unit, London SW3 6JJ, England

[3] Royal Marsden Hosp, Skin Unit, London SW3 6JJ, England

[4] UCL, Canc Res UK Lung Canc Ctr Excellence, Canc Inst, Paul OGorman Bldg,72 Huntley St, London WC1E 6BT, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2017年 / 16卷 / 07期

关键词：

HETEROGENEITY; RESISTANCE;

D O I：

10.1038/nrd.2017.78

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tumour evolution, which results in the existence of multiple distinct populations of cancer cells within the same tumour and the same patient, is increasingly appreciated to have a key role in drug resistance. In this article, we discuss the implications for drug development, including approaches to reduce the likelihood of the emergence of drug resistance.

引用

页码：441 / 442

页数：2

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