Localization of G-protein-coupled receptors in health and disease

被引：66
|
作者：
Edwards, SW [1 ]
Tan, CM [1 ]
Limbird, LE [1 ]
机构：
[1] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 08期
关键词：
D O I：
10.1016/S0165-6147(00)01513-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.
引用
收藏
页码：304 / 308
页数：5
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