Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

被引：7
|
作者：
Zakharchenko, Borys V. [1 ]
Khomenko, Dmytro M. [1 ]
Doroschuk, Roman O. [1 ]
Raspertova, Ilona V. [1 ]
Shova, Sergiu [2 ]
Grebinyk, Anna G. [3 ]
Grynyuk, Iryna I. [1 ]
Prylutska, Svitlana V. [1 ,4 ]
Matyshevska, Olga P. [5 ]
Slobodyanik, Mykola S. [1 ]
Frohme, Marcus [3 ]
Lampeka, Rostislav D. [1 ]
机构：
[1] Taras Shevchenko Natl Univ Kyiv, Volodymyrska St 64-13, UA-01601 Kiev, Ukraine
[2] Petru Poni Inst Macromol Chem, Aleea Gr Ghica Voda 41A, Iasi 700487, Romania
[3] Tech Univ Appl Sci Wildau, Hochschulring 1, D-15745 Wildau, Germany
[4] Natl Univ Life & Environm Sci Ukraine, Heroyiv Oborony St 15, UA-03041 Kiev, Ukraine
[5] NAS Ukraine, Palladin Inst Biochem, Leontovicha St 9, UA-01030 Kiev, Ukraine
来源：
CHEMICAL PAPERS | 2021年 / 75卷 / 09期
关键词：
Palladium; 1; 2; 4-Triazole; NMR spectroscopy; Cytotoxicity; Cancer cells; Hemolysis of erythrocytes; PALLADIUM COMPLEXES; METAL-COMPLEXES; PLATINUM; DRUGS; CHEMISTRY; UPDATE; TRENDS; ACID; DNA;
D O I：
10.1007/s11696-021-01699-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The structure of complex cis-Pd(HLMe)Cl-2 was studied both in solution and in solid state using multinuclear (H-1, C-13, N-15) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HLMe)Cl-2 has a pronounced cytotoxicity toward human leukemic lymphoblast's CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HLMe)Cl-2 is more toxic than cisplatin: its IC50 value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin IC50. Depending on the concentration, cis-Pd(HLMe)Cl-2 is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HLMe)Cl-2 suggest the dependence of the agent's interactions with cells on the molecular structure of palladium ligand and the cell type.
引用
收藏
页码：4899 / 4906
页数：8
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