Intramolecular chiral relay at stereogenic nitrogen:: oxazolidine catalysts derived from Ephedra alkaloids

被引：2

作者：

II, Raleigh W. Parrott ^{[1
]}

Hitchcock, Shawn R. ^{[1
]}

机构：

[1] Illinois State Univ, Dept Chem, Normal, IL 61790 USA

来源：

TETRAHEDRON-ASYMMETRY | 2007年 / 18卷 / 03期

关键词：

ENANTIOSELECTIVE DIETHYLZINC ADDITION; ASYMMETRIC-SYNTHESIS; AMINO-ALCOHOLS; LIGANDS; ALDEHYDES; EPOXIDATION; PROLINE;

D O I：

10.1016/j.tetasy.2006.12.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of oxazolidines have been prepared by reaction of either (1R,2S)-ephedrine or (1S,2S)-pseudoephedrine with salicylaldehyde derivatives. The resultant oxazolidines were used as catalytic ligands in the addition of diethylzinc to a variety of aromatic and aliphatic aldehydes. It was determined that the (1R,2S)-ephedrine based oxazolidine derivative 9 gave the highest enantioselectivities. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：377 / 382

页数：6

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