Background: It has been previously demonstrated that extracorporeal low-energy shock-wave (SW) therapy ameliorates left ventricular (LV) remodeling through enhanced angiogenesis after acute myocardial infarction (AMI) in pigs in vivo. However, it remains to be examined whether SW therapy also exerts anti-inflammatory effects on AMI. Methods and Results: AMI was created by ligating the proximal left anterior descending coronary artery in rats. They were randomly assigned to 2 groups: with (SW group) or without (control group) SW therapy (0.1 mJ/mm(2), 200 shots, 1 Hz to the whole heart at 1, 3 and 5 days after AMI). Four weeks after AMI, SW therapy significantly ameliorated LV remodeling and fibrosis. Histological examinations showed that SW therapy significantly suppressed the infiltration of neutrophils and macrophages at days 3 and 6, in addition to enhanced capillary density in the border area. Molecular examinations demonstrated that SW therapy enhanced the expression of endothelial nitric oxide synthase and suppressed the infiltration of transforming growth factor-beta 1-positive cells early after AMI. SW therapy also upregulated anti-inflammatory cytokines and downregulated pro-inflammatory cytokines in general. Conclusions: These results suggest that low-energy SW therapy suppressed post-MI LV remodeling in rats in vivo, which was associated with anti-inflammatory effects in addition to its angiogenic effects, and demonstrated a novel aspect of the therapy for AMI.
机构:
Sungkyunkwan Univ, Sch Med, Dept Phys Med & Rehabil, Samsung Med Ctr, Seoul, South KoreaSungkyunkwan Univ, Sch Med, Dept Phys Med & Rehabil, Samsung Med Ctr, Seoul, South Korea
Hwang, Ji Hye
Lee, Yong-Taek
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Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Seoul, South KoreaSungkyunkwan Univ, Sch Med, Dept Phys Med & Rehabil, Samsung Med Ctr, Seoul, South Korea
机构:
Univ Western Ontario, Sch Phys Therapy, 1201 Western Rd, London, ON N6G 1H1, CanadaUniv Western Ontario, Sch Phys Therapy, 1201 Western Rd, London, ON N6G 1H1, Canada
Burton, Ann-Marie
Overend, Tom
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Univ Western Ontario, Sch Phys Therapy, 1201 Western Rd, London, ON N6G 1H1, CanadaUniv Western Ontario, Sch Phys Therapy, 1201 Western Rd, London, ON N6G 1H1, Canada
机构:
Southern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Tang, WaiJiao
Zeng, Lu
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Southern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Nanchang Univ, Dept Pharm, Ganzhou Peoples Hosp, Ganzhou 341000, Jiangxi, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Zeng, Lu
Yin, JinJin
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Guangzhou Med Univ, Affiliated Hosp 3, Dept Pharm, Guangzhou 510150, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Yin, JinJin
Yao, YuFa
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Southern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Yao, YuFa
Feng, LiJuan
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Southern Med Univ, Beijiao Hosp, Dept Pharm, Guangzhou 528311, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Feng, LiJuan
Yao, XiaoRui
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Southern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Yao, XiaoRui
Sun, XiaoMin
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Southern Med Univ, Dept Tradit Chinese Med, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China
Sun, XiaoMin
Zhou, BenJie
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Southern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R ChinaSouthern Med Univ, Ctr Drug Res & Dev, Zhujiang Hosp, Guangzhou 510282, Guangdong, Peoples R China