Indolic metabolites from the new marine bacterium Roseivirga echinicomitans KMM 6058T

被引：14
|
作者：
Oleinikova, G. K.
Ivchuk, O. I.
Denisenko, V. A.
Chaikina, E. L.
Menzorova, N. I.
Nedashkovskaya, O. I.
Kuznetsova, T. A.
机构：
[1] Russian Acad Sci, Far Eastern Div, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
[2] Far Eastern State Univ, Vladivostok 690000, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2006年 / 42卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
acetyltryptamine; NMR spectroscopy; marine bacterium Roseivirga echinicomitans; indolic metabolites; biological activity;
D O I：
10.1007/s10600-006-0260-x
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
N-Acetyl-(1) and N,N-diacetyl-(2) tryptamines were isolated from the butanol extract of culture medium of the new marine bacterium Roseivirga echinicomitans KMM 6058(T). The structures of the compounds were proved using mass spectrometry, UV, PMR, and C-13 NMR spectroscopy and by comparing these data with mass and NMR spectra of synthetic samples of 1 and 2. Compound 2 was isolated from a natural source and synthesized for the first time. The cytotoxic activity of the compounds was studied using Erlich carcinoma tumor cells, murine erythrocytes, and sperm and egg cells of the sea urchin Strongylocentrotus intermedius.
引用
收藏
页码：713 / 717
页数：5
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