The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats

被引：21

作者：

Hollmann, M

Simmerl, E

Schäfer, U

Schäfer, MA

机构：

[1] Univ Gottingen, Zool Inst Entwicklungsbiol 3, D-37073 Gottingen, Germany

[2] Univ Dusseldorf, Inst Genet, D-40225 Dusseldorf, Germany

[3] Univ Kassel, D-34132 Kassel, Germany

来源：

MOLECULAR GENETICS AND GENOMICS | 2002年 / 268卷 / 04期

关键词：

Drosophila melanogaster; wds; l(1)zw8; l(1)3Ad; WD-repeat;

D O I：

10.1007/s00438-002-0768-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and characterized the will die slowly (wds) gene of Drosophila melanogaster, formerly known as 1(1)zw8 or 1(1)3Ad. The gene codes for a 2.0kb RNA that is transcribed at all stages of development. The RNA has been localized by in situ hybridization to imaginal discs, larval brain, to nurse cells in the ovary, and to spermatogonia and spermatocytes in the testis. The putative translation product contains seven WD-repeats and is, therefore, a new member of the family of WD-proteins. Clear homologues of the Drosophila WDS protein exist in three other fully sequenced higher eukaryotes-human, Caenorhabditis elegans and Arabidopsis. A genomic fragment containing the wds transcription unit is able to rescue two different lethal wds alleles, thus proving that we have indeed isolated the wds gene.

引用

页码：425 / 433

页数：9

共 31 条

[21] The WD-repeat protein Pfs2p bridges two essential factors within the yeast pre-mRNA 3′-end-processing complex
Ohnacker, M
Barabino, SML
Preker, PJ
Keller, W
EMBO JOURNAL, 2000, 19 (01): : 37 - 47
[22] The essential gene wda encodes a WD40 repeat subunit of Drosophila SAGA required for histone H3 acetylation
Guelman, Sebastian
Suganuma, Tamaki
Florens, Laurence
Weake, Vikki
Swanson, Selene K.
Washburn, Michael P.
Abmayr, Susan M.
Workman, Jerry L.
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (19) : 7178 - 7189
[23] THE GENE UPSTREAM OF DMRP128 CODES FOR A NOVEL GTP-BINDING PROTEIN OF DROSOPHILA-MELANOGASTER
SOMMER, KA
PETERSEN, G
BAUTZ, EKF
MOLECULAR & GENERAL GENETICS, 1994, 242 (04): : 391 - 398
[24] Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis
Gross, C
De Baere, E
Lo, A
Chang, WH
Messiaen, L
DNA AND CELL BIOLOGY, 2001, 20 (01) : 41 - 52
[25] THE SAP47 GENE OF DROSOPHILA-MELANOGASTER CODES FOR A NOVEL CONSERVED NEURONAL PROTEIN ASSOCIATED WITH SYNAPTIC TERMINALS
REICHMUTH, C
BECKER, S
BENZ, M
DEBEL, K
REISCH, D
HEIMBECK, G
HOFBAUER, A
KLAGGES, B
PFLUGFELDER, GO
BUCHNER, E
MOLECULAR BRAIN RESEARCH, 1995, 32 (01): : 45 - 54
[26] THE CPC-2 GENE OF NEUROSPORA-CRASSA ENCODES A PROTEIN ENTIRELY COMPOSED OF WD-REPEAT SEGMENTS THAT IS INVOLVED IN GENERAL AMINO-ACID CONTROL AND FEMALE FERTILITY
MULLER, F
KRUGER, D
SATTLEGGER, E
HOFFMANN, B
BALLARIO, P
KANAAN, M
BARTHELMESS, IB
MOLECULAR & GENERAL GENETICS, 1995, 248 (02): : 162 - 173
[27] THE NEUROGENIC GENE-DELTA OF DROSOPHILA-MELANOGASTER IS EXPRESSED IN NEUROGENIC TERRITORIES AND ENCODES A PUTATIVE TRANSMEMBRANE PROTEIN WITH EGF-LIKE REPEATS
VASSIN, H
BREMER, KA
KNUST, E
CAMPOSORTEGA, JA
EMBO JOURNAL, 1987, 6 (11): : 3431 - 3440
[28] A NOVEL INTRACELLULAR ANTIPROLIFERATIVE PROTEIN, PROHIBITION, IS THE MAMMALIAN EQUIVALENT OF THE DROSOPHILA-MELANOGASTER GENE PRODUCT-CC ESSENTIAL FOR DEVELOPMENT
WOOD, CM
WHITE, JJ
STEWART, DA
NUELL, MJ
LEDBETTER, DH
EDDY, RL
SHOWS, TB
MORTON, CC
DANNER, DB
AMERICAN JOURNAL OF HUMAN GENETICS, 1991, 49 (04) : 423 - 423
[29] THE GENE SERRATE ENCODES A PUTATIVE EGF-LIKE TRANSMEMBRANE PROTEIN ESSENTIAL FOR PROPER ECTODERMAL DEVELOPMENT IN DROSOPHILA-MELANOGASTER
FLEMING, RJ
SCOTTGALE, TN
DIEDERICH, RJ
ARTAVANISTSAKONAS, S
GENES & DEVELOPMENT, 1990, 4 (12A) : 2188 - 2201
[30] The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis
Munn, K
Steward, R
GENETICS, 2000, 156 (01) : 245 - 256

← 1 2 3 4 →