Phase 1b/2 trial of BI 836845, an insulin-like growth factor (IGF) ligand-neutralising antibody, in combination with exemestane and everolimus in postmenopausal women with hormone receptor-positive, locally advanced or metastatic breast cancer: Preliminary results of the Phase 1b part

被引:0
|
作者
Cortes, J. [1 ,2 ]
Martinez Janesz, N. [1 ]
Sablin, M. P. [3 ]
Perez-Fidalgo, J. A. [4 ]
Neven, P. [5 ]
Hedayati, E. [6 ,7 ]
Ballester, A. [8 ]
Ehrhart, M. P. [9 ,10 ]
Huang, D. Chin-Lun [11 ]
Bogenrieder, T. [12 ]
Schmid, P. [13 ]
机构
[1] Ramon y Cajal Univ Hosp, Dept Med Oncol, Madrid, Spain
[2] Vall dHebron Inst Oncol VHIO, Dept Oncol, Barcelona, Spain
[3] Inst Curie, Dept Med Oncol, Paris, France
[4] Hosp Clin Univ Valencia, Dept Haematol & Med Oncol, Valencia, Spain
[5] UZ Leuven, Multidisciplinary Breast Ctr, Leuven, Belgium
[6] Karolinska Inst, Stockholm, Sweden
[7] Univ Hosp, Dept Oncol Pathol, Stockholm, Sweden
[8] Boehringer Ingelheim Espana SA, Dept Med Oncol, Barcelona, Spain
[9] Staburo GmbH, Munich, Germany
[10] Boehringer Ingelheim Pharma GmbH & Co KG, St Joseph, MO USA
[11] Boehringer Ingelheim Taiwan Ltd, Med, Taipei, Taiwan
[12] Boehringer Ingelheim RCV, Med, Vienna, Austria
[13] Queen Mary Univ London, Ctr Expt Canc Med, Barts Canc Inst, London, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
389
引用
收藏
页码:S112 / S112
页数:1
相关论文
共 50 条
  • [21] Gedatolisib in combination with palbociclib and endocrine therapy in women with hormone receptor-positive, HER2-negative advanced breast cancer: results from the dose expansion groups of an open-label, phase 1b study
    Layman, Rachel M.
    Han, Hyo S.
    Rugo, Hope S.
    Stringer-Reasor, Erica M.
    Specht, Jennifer M.
    Dees, Claire
    Kabos, Peter
    Suzuki, Samuel
    Mutka, Sarah C.
    Sullivan, Brian F.
    Gorbatchevsky, Igor
    Wesolowski, Robert
    LANCET ONCOLOGY, 2024, 25 (04): : 474 - 487
  • [22] Safety of everolimus plus exemestane in patients with hormone-receptor-positive, HER2-negative locally advanced or metastatic breast cancer: results of phase IIIb BALLET trial in Spain
    E. Ciruelos
    M. Vidal
    E. Martínez de Dueñas
    N. Martínez-Jáñez
    Y. Fernández
    J. A. García-Sáenz
    L. Murillo
    F. Carabantes
    A. Beliera
    R. Fonseca
    J. Gavilá
    Clinical and Translational Oncology, 2018, 20 : 753 - 760
  • [23] PALVEN: phase 1b trial of palbociclib, letrozole and venetoclax in estrogen receptor- and BCL2-positive advanced breast cancer
    Muttiah, Christine
    Whittle, James R.
    Oakman, Catherine
    Lindeman, Geoffrey J.
    FUTURE ONCOLOGY, 2022, 18 (15) : 1805 - 1816
  • [24] Safety of everolimus plus exemestane in patients with hormone-receptor-positive, HER2-negative locally advanced or metastatic breast cancer: results of phase IIIb BALLET trial in Spain
    Ciruelos, E.
    Vidal, M.
    Martinez de Duenas, E.
    Martinez-Janez, N.
    Fernandez, Y.
    Garcia-Saenz, J. A.
    Murillo, L.
    Carabantes, F.
    Beliera, A.
    Fonseca, R.
    Gavila, J.
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2018, 20 (06): : 753 - 760
  • [25] Randomized Phase II Trial of Letrozole plus Anti-MUC1 Antibody AS1402 in Hormone Receptor-Positive Locally Advanced or Metastatic Breast Cancer
    Ibrahim, Nuhad K.
    Yariz, Kemal O.
    Bondarenko, Ihor
    Manikhas, Alexei
    Semiglazov, Vladimir
    Alyasova, Anna
    Komisarenko, Volodymyr
    Shparyk, Yaroslav
    Murray, James Lee
    Jones, David
    Senderovich, Shai
    Chau, Albert
    Erlandsson, Fredrik
    Acton, Gary
    Pegram, Mark
    CLINICAL CANCER RESEARCH, 2011, 17 (21) : 6822 - 6830
  • [26] Alpelisib plus letrozole in estrogen receptor-Positive (ER plus ), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (aBC): Safety and preliminary efficacy analysis from a phase 1b trial
    Juric, Dejan
    Goncalves, Anthony
    Hamilton, Erika
    Boni, Valentina
    Mayer, Ingrid A.
    Turri, Sabine
    Wang, Yingbo
    Vogl, Florian D.
    Sellami, Dalila
    Campone, Mario
    CANCER RESEARCH, 2018, 78 (04)
  • [27] XENERA-1: a randomised double-blind Phase II trial of xentuzumab in combination with everolimus and exemestane versus everolimus and exemestane in patients with hormone receptor-positive/HER2-negative metastatic breast cancer and non-visceral disease
    Peter Schmid
    Javier Cortes
    Ana Joaquim
    Noelia Martínez Jañez
    Serafín Morales
    Tamara Díaz-Redondo
    Sibel Blau
    Patrick Neven
    Julie Lemieux
    José Ángel García-Sáenz
    Lowell Hart
    Tsvetan Biyukov
    Navid Baktash
    Dan Massey
    Howard A. Burris
    Hope S. Rugo
    Breast Cancer Research, 25
  • [28] XENERA-1: a randomised double-blind Phase II trial of xentuzumab in combination with everolimus and exemestane versus everolimus and exemestane in patients with hormone receptor-positive/HER2-negative metastatic breast cancer and non-visceral disease
    Schmid, Peter
    Cortes, Javier
    Joaquim, Ana
    Janez, Noelia Martinez
    Morales, Serafin
    Diaz-Redondo, Tamara
    Blau, Sibel
    Neven, Patrick
    Lemieux, Julie
    Garcia-Saenz, Jose Angel
    Hart, Lowell
    Biyukov, Tsvetan
    Baktash, Navid
    Massey, Dan
    Burris, Howard A., III
    Rugo, Hope S.
    BREAST CANCER RESEARCH, 2023, 25 (01)
  • [29] Interim Results from a Phase 1b/2a Study of Trastuzumab Emtansine and Docetaxel, With and Without Pertuzumab, in Patients With HER2-Positive Locally Advanced or Metastatic Breast Cancer
    Martin, M.
    Garcia-Saenz, J. A.
    Dewar, J. A.
    Albanell, J.
    Limentani, S. A.
    Strasak, A.
    Patre, M.
    Branle, F.
    Fumoleau, P.
    CANCER RESEARCH, 2012, 72
  • [30] A phase 1b/2 trial of SHR-1701 in combination with gemcitabine and nab-paclitaxel in patients with untreated locally advanced or metastatic pancreatic cancer.
    Zhou, Jun
    Yu, Xianjun
    Li, Zhihua
    Zhou, Yuhong
    Li, Jialin
    Xue, Ran
    Xia, Ye
    Han, Hongxia
    Wu, Yiwen
    Shen, Lin
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16) : E16264 - E16264