γ-radiation-induced irreparable damage to DNA of HeLa cells

被引：1
|
作者：
Struchkov, VA [1 ]
Demidova, NI [1 ]
Strazhevskaya, NB [1 ]
机构：
[1] Russian Acad Med Sci, Oncol Res Ctr, Inst Expt Diagnosis & Therapy Tumors, Cellular Metab Lab, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1997年 / 124卷 / 07期
关键词：
gamma-radiation; DNA damage; HeLa cells;
D O I：
10.1007/BF02445057
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Exposure of HeLa cells to gamma-radiation at 0.1 Gy and then at 5 Gy reduces their ability to repair double-strand DNA breaks to a greater extent than irradiation with a single dose of 5 Gy. Modifying effects of 0.1 Gy on double-strand DNA breaks and on cell survival are observed after irradiation during logarithmic but not stationary phase of growth. Primary gamma-induced irreparable double-strand breaks correlates with cell survival regardless the irradiation regime. It is suggested that such a damage is primarily responsible for reproductive death of HeLa cells.
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页码：668 / 671
页数：4
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