Long-term risk of end-stage renal diseases with maintenance dialysis among chronic hepatitis C patients after antiviral therapy in Taiwan

被引：3

作者：

Hsieh, Meng-Hsuan ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Bair, Ming-Jong ^{[14
]}

Tsai, Pei-Chien ^{[2
,3
]}

Tseng, Kuo-Chih ^{[32
]}

Lo, Ching-Chu ^{[19
]}

Chen, Chi-Yi ^{[20
]}

Kuo, Hsing-Tao ^{[23
]}

Hung, Chao-Hung ^{[9
,10
]}

Lai, Hsueh-Chou ^{[18
]}

Peng, Cheng-Yuan ^{[18
]}

Wang, Jing-Houng ^{[21
]}

Chen, Jyh-Jou ^{[33
]}

Lee, Pei-Lun ^{[33
]}

Chien, Rong-Nan ^{[24
]}

Yang, Chi-Chieh ^{[16
]}

Lo, Gin-Ho ^{[11
,12
]}

Kao, Jia-Horng ^{[25
,26
]}

Liu, Chun-Jen ^{[25
,26
]}

Liu, Chen-Hua ^{[25
,26
]}

Yan, Sheng-Lei ^{[17
]}

Lin, Chun-Yen ^{[24
]}

Su, Wei-Wen ^{[15
]}

Chu, Cheng-Hsin ^{[27
]}

Chen, Chih-Jen ^{[27
]}

Tung, Shui-Yi ^{[9
,10
]}

Tai, Chi-Ming ^{[11
,12
]}

Lin, Chih-Wen ^{[11
,12
]}

Cheng, Pin-Nan ^{[22
]}

Chiu, Yen-Cheng ^{[22
]}

Wang, Chia-Chi ^{[30
,31
]}

Cheng, Jin-Shiung ^{[13
]}

Tsai, Wei-Lun ^{[13
]}

Lin, Han-Chieh ^{[28
]}

Huang, Yi-Hsiang ^{[28
,29
]}

Yeh, Ming-Lun ^{[2
,3
,4
,5
,6
,7
]}

Huang, Chung-Feng ^{[2
,3
,4
,5
,6
,7
]}

Huang, Jee-Fu ^{[2
,3
,4
,5
,6
,7
]}

Dai, Chia-Yen ^{[2
,3
,4
,5
,6
,7
]}

Yu, Ming-Lung ^{[2
,3
,4
,5
,6
,7
]}

Chuang, Wan-Long ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Kaohsiung Med Univ Hosp, Hlth Management Ctr, Dept Occupat & Environm Med, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Internal Med, Hepatobiliary Div, Kaohsiung, Taiwan

[3] Kaohsiung Med Univ Hosp, Hepatitis Ctr, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Sch Med, Coll Med, Kaohsiung, Taiwan

[5] Kaohsiung Med Univ, Hepatitis Res Ctr, Coll Med, Kaohsiung, Taiwan

[6] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res, Kaohsiung, Taiwan

[8] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan

[9] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Hepatogastroenterol, Kaohsiung, Taiwan

[10] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan

[11] I Shou Univ, E Da Hosp, Dept Med, Div Gastroenterol & Hepatol, Kaohsiung, Taiwan

[12] I Shou Univ, Sch Med, Coll Med, Kaohsiung, Taiwan

[13] Kaohsiung Vet Gen Hosp, Div Gastroenterol & Hepatol, Dept Med, Kaohsiung, Taiwan

[14] Taitung Mackay Mem Hosp, Div Gastroenterol, Dept Internal Med, Taitung, Taiwan

[15] Changhua Christian Hosp, Div Gastroenterol, Dept Internal Med, Changhua, Taiwan

[16] Show Chwan Mem Hosp, Div Gastroenterol, Dept Internal Med, Changhua, Taiwan

[17] Chang Bing Show Chwan Mem Hosp, Div Gastroenterol, Dept Internal Med, Changhua, Taiwan

[18] China Med Univ Hosp, Div Hepatogastroenterol, Dept Internal Med, Taichung, Taiwan

[19] St Martin Porres Hosp Daya, Dept Internal Med, Daya, Taiwan

[20] Chiayi Christian Hosp, Dept Internal Med, Chiayi, Taiwan

[21] ChiaYi Chang Gung Mem Hosp, Div Hepatogastroenterol, Dept Internal Med, Chiayi, Taiwan

[22] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, Tainan, Taiwan

[23] Chi Mei Med Ctr, Div Hepatogastroenterol, Dept Internal Med, Tainan, Taiwan

[24] Chang Gung Mem Hosp, Div Hepatol, Dept Gastroenterol & Hepatol, Linkou Med Ctr, Keelung, Taiwan

[25] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei, Taiwan

[26] Natl Taiwan Univ Hosp, Div Gastroenterol & Hepatol, Taipei, Taiwan

[27] MacKay Mem Hosp, Div Gastroenterol, Dept Internal Med, Taipei, Taiwan

[28] Taipei Vet Gen Hosp, Div Gastroenterol & Hepatol, Dept Med, Taipei, Taiwan

[29] Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan

[30] Buddhist Tzuchi Med Fdn, Div Gastroenterol, Taipei Tzuchi Hosp, Dept Internal Med, New Taipei, Taiwan

[31] Tzu Chi Univ, Sch Med, Hualien, Taiwan

[32] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Gastroenterol, Chiayi, Taiwan

[33] Chi Mei Med Ctr, Div Gastroenterol & Hepatol, Tainan, Taiwan

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2021年 / 36卷 / 08期

关键词：

chronic kidney disease; end‐ stage renal disease; hepatitis C virus; interferon; VIRUS-INFECTION; GLUCOSE ABNORMALITIES; VIRAL-HEPATITIS; FIBROSIS; OUTCOMES; ASSOCIATION; NATIONWIDE; GENOTYPE; COHORT; AREA;

D O I：

10.1111/jgh.15469

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aim Chronic hepatitis C virus (HCV) infection is associated with impaired renal function. The aim of this study is to explore the risk of and factors associated with end-stage renal diseases (ESRD) under maintenance dialysis among HCV patients after anti-HCV therapy. Methods A total of 12 696 HCV-infected patients with interferon-based therapy, including 9679 (76.2%) achieving sustained virological response (SVR), were enrolled from 23 hospitals in Taiwan. Results During a mean follow-up period of 5.3 years (67 554 person-years), the annual incidence of 4.1/10 000 person-years, 4.0/10 000 and 4.7/10 000 person-years among SVR patients and non-SVR patients, respectively. History of diabetes and baseline estimated glomerular filtration rate < 60 mL/min/m(2), instead of SVR, were the significant risk factors for developing ESRD with maintenance dialysis after anti-HCV therapy (adjusted hazard ratio 7.75 and 9.78). Conclusion Diabetes and baseline impaired renal function were strongly associated with progression to ESRD with maintenance dialysis among chronic HCV-infected patients after antiviral therapy.

引用

页码：2247 / 2254

页数：8

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